Studies on arylfuran derivatives. Part VII. Synthesis and characterization of some Mannich bases carrying halophenylfuryl moieties as promising antibacterial agents

B. Shivarama Holla; M. K. Shivananda; M. Shalini Shenoy; Georgy Antony

doi:10.1016/S0014-827X(98)00058-5

Studies on arylfuran derivatives. Part VII. Synthesis and characterization of some Mannich bases carrying halophenylfuryl moieties as promising antibacterial agents

B. Shivarama Holla, M. K. Shivananda, M. Shalini Shenoy, Georgy Antony

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

A series of 4-[5-(halophenyl)-2-furfurylidene)]amino-3-mercapto-5-substituted-1,2,4 -triazoles (3) were synthesized. Aminomethylation of 3 with formaldehyde and a secondary amine furnished Mannich bases, 4. Both Schiff bases and Mannich bases were characterized on the basis of IR, NMR, mass spectral data and elemental analysis. All the newly synthesized compounds were tested for their antibacterial activities. Some of them carrying morpholino and N-methylpiperazino residues were found to be promising antibacterial agents.

Original language	English
Pages (from-to)	531-535
Number of pages	5
Journal	Farmaco
Volume	53
Issue number	8-9
DOIs	https://doi.org/10.1016/S0014-827X(98)00058-5
Publication status	Published - 30-08-1998

All Science Journal Classification (ASJC) codes

Pharmaceutical Science
Drug Discovery

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AU - Shenoy, M. Shalini

AU - Antony, Georgy

PY - 1998/8/30

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Studies on arylfuran derivatives. Part VII. Synthesis and characterization of some Mannich bases carrying halophenylfuryl moieties as promising antibacterial agents

Abstract

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