TY - JOUR
T1 - Studies on solubility parameter of amoxycillin trihydrate: Influence on in vitro release and antibacterial activity
AU - Karanth, H.
AU - Josyula, V.R.
N1 - Cited By :5
Export Date: 10 November 2017
CODEN: IJSID
Correspondence Address: Josyula, V. R.; Department of Pharmacy Management, College of Pharmaceutical Sciences, MAHE, Manipal-576 104, India; email: [email protected]
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PY - 2005
Y1 - 2005
N2 - Amoxycillin trihydrate, a broad spectrum antibiotic, is a poorly water-soluble drug and has low bioavailability on oral administration. Solubility parameter of the drug (δ2) was evaluated in blends of ethyl acetate-propylene glycol and water-propylene glycol in the ratios 100:0, 75:25, 50:50, 25:75 and 0:100. The results obtained were compared with the δ2 values obtained using Molar Volume method and Fedor's group substitution method. Ethyl acetate-propylene glycol (75:25) was found to give maximum solubility with an experimental value of 13.32 H in comparison to the theoretical values of 13.25 H by molar volume method and 15.46 H from Fedor's group substitution method. In vitro drug release studies and antibacterial effect were evaluated with an intention to study the effect of the solvent blends on the drug release and its activity. In the in vitro studies, the water-propylene glycol (100:0) and the ethyl acetate-propylene glycol (50:50) ratios gave maximum release of the drug in their respective blends. The results of the in vitro studies correlated with the antibiotic Study conducted on both binary blends.
AB - Amoxycillin trihydrate, a broad spectrum antibiotic, is a poorly water-soluble drug and has low bioavailability on oral administration. Solubility parameter of the drug (δ2) was evaluated in blends of ethyl acetate-propylene glycol and water-propylene glycol in the ratios 100:0, 75:25, 50:50, 25:75 and 0:100. The results obtained were compared with the δ2 values obtained using Molar Volume method and Fedor's group substitution method. Ethyl acetate-propylene glycol (75:25) was found to give maximum solubility with an experimental value of 13.32 H in comparison to the theoretical values of 13.25 H by molar volume method and 15.46 H from Fedor's group substitution method. In vitro drug release studies and antibacterial effect were evaluated with an intention to study the effect of the solvent blends on the drug release and its activity. In the in vitro studies, the water-propylene glycol (100:0) and the ethyl acetate-propylene glycol (50:50) ratios gave maximum release of the drug in their respective blends. The results of the in vitro studies correlated with the antibiotic Study conducted on both binary blends.
M3 - Article
SN - 0250-474X
VL - 67
SP - 342
EP - 345
JO - Indian Journal of Pharmaceutical Sciences
JF - Indian Journal of Pharmaceutical Sciences
IS - 3
ER -