Supercontinuum generation in macromolecular media

C. Santhosh, A. K. Dharmadhikari, J. A. Dharmadhikari, K. Alti, D. Mathur

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)


The interaction of intense, ultrashort (femtosecond) pulses of infrared light with water leads to the generation of a white light supercontinuum due to nonlinear optical effects. This supercontinuum extends over the wavelength range 400-900 nm. The blue-sided components of this supercontinuum are due to laser-induced plasma effects and are found to sensitively depend on the presence in water of minute quantities of protein dopants (dilutions of 0.025%-0.1%). Salivary proteins like mucin and immunoglobulin-A lead to pronounced suppression of the blue-sided components, while proteins found in blood serum, such as transferrin, immunoglobulin G (IgG) and human serum albumin (HSA), do not show any such suppression. It is postulated that major salivary proteins have a propensity to efficiently scavenge plasma electrons and thereby extinguish the plasma that is formed upon laser irradiation.

Original languageEnglish
Pages (from-to)427-432
Number of pages6
JournalApplied Physics B: Lasers and Optics
Issue number3
Publication statusPublished - 01-05-2010

All Science Journal Classification (ASJC) codes

  • General Physics and Astronomy
  • Physics and Astronomy (miscellaneous)


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