Supercritical fluid technology: Concepts and pharmaceutical applications

Praful Balavant Deshpande, G. Aravind Kumar, Averineni Ranjith Kumar, Gopal Venkatesh Shavi, Arumugam Karthik, Meka Sreenivasa Reddy, Nayanabhirama Udupa

Research output: Contribution to journalReview articlepeer-review

37 Citations (Scopus)


In light of environmental apprehension, supercritical fluid technology (SFT) exhibits excellent opportunities to accomplish key objectives in the drug delivery sector. Supercritical fluid extraction using carbon dioxide (CO2) has been recognized as a green technology. It is a clean and versatile solvent with gas-like diffusivity and liquid-like density in the supercritical phase, which has provided an excellent alternative to the use of chemical solvents. The present commentary provides an overview of different techniques using supercritical fluids and their future opportunity for the drug delivery industry. Some of the emerging applications of SFT in pharmaceuticals, such as particle design, drug solubilization, inclusion complex, polymer impregnation, polymorphism, drug extraction process, and analysis, are also covered in this review. The data collection methods are based on the recent literature related to drug delivery systems using SFT platforms. SFT has become a much more versatile and environmentally attractive technology that can handle a variety of complicated problems in pharmaceuticals. This cutting-edge technology is growing predominantly to surrogate conventional unit operations in relevance to the pharmaceutical production process.

Original languageEnglish
Pages (from-to)333-344
Number of pages12
JournalPDA Journal of Pharmaceutical Science and Technology
Issue number3
Publication statusPublished - 05-2011

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science
  • General Medicine


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