TY - JOUR
T1 - Supramolecular dendrimers based novel platforms for effective oral delivery of therapeutic moieties
AU - Fernandes, Gasper
AU - Pandey, Abhijeet
AU - Kulkarni, Sanjay
AU - Mutalik, Sadhana P.
AU - Nikam, Ajinkya Nitin
AU - Seetharam, Raviraja N.
AU - Kulkarni, Smita S.
AU - Mutalik, Srinivas
N1 - Funding Information:
The authors are thankful to i) Manipal Academy of Higher Education (MAHE), Manipal, India (for Postdoctoral Fellowship to Dr. Abhijeet Pandey and Dr. TMA Pai Doctoral Fellowship to Gasper Fernandes, Ajinkya N Nikam, and Sanjay Kulkarni), and ii) Department of Science and Technology, Government of India, New Delhi (for INSPIRE fellowship to Sadhana P Mutalik) The authors are also thankful to Manipal College of Pharmaceutical Sciences, MAHE, Manipal, India for providing the necessary facilities. The authors gratefully acknowledge BioRender.com for providing an online platform to create images.
Publisher Copyright:
© 2021 Elsevier B.V.
PY - 2021/8
Y1 - 2021/8
N2 - Dendrimers are globular three-dimensional synthetic macromolecules that are highly branched with a definite molecular weight. The distinct physicochemical properties and advancements in the synthesis of a variety of biodegradable dendritic scaffolds were studied in several biomedical applications, primarily for the delivery of drug and protein to targeted sites. However, in the context of oral delivery, the knowledge of pharmacokinetics of the dendrimer and its interaction with cellular components is obscure, and therefore further studies will uplift/elevate the effective clinical translation potential of dendrimers. In this review, we showcase the unique tuneable physicochemical properties of dendrimers alongside the advanced synthetic routes and diverse classes of dendritic scaffolds. In particular, the interaction of dendrimer with biological fluids, cellular uptake, toxicity, and degradation mechanisms are also discussed considering oral delivery/application. We focused exclusively on the influence of dendrimer surface groups and their charge, core chemistry, combination with oral permeation enhancers, effect of lipidation as well as dendrimer conjugation with other nanocarriers as an attempt to improve the therapeutic efficacy of drugs via the oral route. Majority of studies utilize Polyamidoamine (PAMAM) dendrimer to improve the oral bioavailability of drugs; however, toxicity limits its application. Therefore, exploring other classes of dendrimers along with the use of self-assembling dendrimers has been discussed in recent advancements and future perspectives for successful clinical translation of dendrimers in oral delivery.
AB - Dendrimers are globular three-dimensional synthetic macromolecules that are highly branched with a definite molecular weight. The distinct physicochemical properties and advancements in the synthesis of a variety of biodegradable dendritic scaffolds were studied in several biomedical applications, primarily for the delivery of drug and protein to targeted sites. However, in the context of oral delivery, the knowledge of pharmacokinetics of the dendrimer and its interaction with cellular components is obscure, and therefore further studies will uplift/elevate the effective clinical translation potential of dendrimers. In this review, we showcase the unique tuneable physicochemical properties of dendrimers alongside the advanced synthetic routes and diverse classes of dendritic scaffolds. In particular, the interaction of dendrimer with biological fluids, cellular uptake, toxicity, and degradation mechanisms are also discussed considering oral delivery/application. We focused exclusively on the influence of dendrimer surface groups and their charge, core chemistry, combination with oral permeation enhancers, effect of lipidation as well as dendrimer conjugation with other nanocarriers as an attempt to improve the therapeutic efficacy of drugs via the oral route. Majority of studies utilize Polyamidoamine (PAMAM) dendrimer to improve the oral bioavailability of drugs; however, toxicity limits its application. Therefore, exploring other classes of dendrimers along with the use of self-assembling dendrimers has been discussed in recent advancements and future perspectives for successful clinical translation of dendrimers in oral delivery.
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U2 - 10.1016/j.jddst.2021.102647
DO - 10.1016/j.jddst.2021.102647
M3 - Review article
AN - SCOPUS:85108292575
SN - 1773-2247
VL - 64
JO - Journal of Drug Delivery Science and Technology
JF - Journal of Drug Delivery Science and Technology
M1 - 102647
ER -