TY - JOUR
T1 - Surface architectured black phosphorous nanoconstructs based smart and versatile platform for cancer theranostics
AU - Pandey, Abhijeet
AU - Nikam, Ajinkya Nitin
AU - Padya, Bharath Singh
AU - Kulkarni, Sanjay
AU - Fernandes, Gasper
AU - Shreya, Ajjappla Basavaraj
AU - García, Mónica C.
AU - Caro, Carlos
AU - Páez-Muñoz, Jose Maria
AU - Dhas, Namdev
AU - García-Martín, Maria Luisa
AU - Mehta, Tejal
AU - Mutalik, Srinivas
N1 - Funding Information:
The authors are thankful to i) Manipal Academy of Higher Education (MAHE), Manipal, India (for Postdoctoral Fellowship to Dr Abhijeet Pandey and Dr TMA Pai Doctoral Fellowship to Ajinkya Nikam, Gasper Fernandes and Sanjay Kulkarni), ii) All India Council for Technical Education (AICTE), Government of India, New Delhi (for National Doctoral Fellowship to Bharath S Padya). Dr Garc?a MC is member of CONICET scientific career and she wishes to acknowledge the assistance of the CONICET and the Universidad Nacional de Cordoba (UNC), both of which provided facilities for this work. The authors are also thankful to Manipal and Manipal College of Pharmaceutical Sciences, MAHE, Manipal, India for providing necessary facilities. The authors acknowledge BioRender for providing online platform to create images. The authors report no conflict of interest.
Funding Information:
The authors are thankful to i) Manipal Academy of Higher Education (MAHE) , Manipal, India (for Postdoctoral Fellowship to Dr Abhijeet Pandey and Dr TMA Pai Doctoral Fellowship to Ajinkya Nikam, Gasper Fernandes and Sanjay Kulkarni), ii) All India Council for Technical Education (AICTE) , Government of India, New Delhi (for National Doctoral Fellowship to Bharath S Padya). Dr García MC is member of CONICET scientific career and she wishes to acknowledge the assistance of the CONICET and the Universidad Nacional de Cordoba (UNC), both of which provided facilities for this work. The authors are also thankful to Manipal and Manipal College of Pharmaceutical Sciences, MAHE, Manipal, India for providing necessary facilities. The authors acknowledge BioRender for providing online platform to create images.
Publisher Copyright:
© 2021 Elsevier B.V.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/5/15
Y1 - 2021/5/15
N2 - Black Phosphorous has recently gained the attention in the field of 2D nanomaterials owing to its exceptional structure and properties. Specifically, its features like drug loading efficiency, biocompatibility, optical, mechanical, electrical, thermal and phototherapeutic properties contribute to its rising demand as potential alternative to the graphene-based 2D nanomaterials in biomedical applications. Though the BP's outlook appears promising, its practical applicability is highly challenging. In this review we have discussed the different strategies for synthesis of BP and then briefed its unique properties which renders it a potential platform for the biomedical application. We then discuss the importance of heterogeneous doping on improving the stability of BP against chemical degradation and enhancing its photoelectric properties. Meanwhile, BP-based nanoconjugates, stimuli responsive nanoplatforms, therapeutic, imaging and biosensing platforms are the domains of special and comprehensive interest for versatile biomedical applications of BP. The physicochemical interactions at the nano-bio interface like protein corona formation on the surface on nanoparticles due to interaction with the plasma proteins and others play a crucial role in the biological effects of BP. Hence, we have also discussed the recent studies on interactions between Black phosphorus based nanoconstructs with various biological molecules. Further, it is vital to consider the fact that, though biocompatible, BP-nanomaterials can induce inflammatory responses and exhibit toxicity in dose and time dependant manner. Therefore, we have briefed the biodegradation and toxicological aspects of BP to enlighten the readers about the safety and toxicity of black phosphorous. The future developments of this 2D nanomaterial will not only serve as a boon for oncology, but also functions as a potential nanoplatform for other biomedical applications.
AB - Black Phosphorous has recently gained the attention in the field of 2D nanomaterials owing to its exceptional structure and properties. Specifically, its features like drug loading efficiency, biocompatibility, optical, mechanical, electrical, thermal and phototherapeutic properties contribute to its rising demand as potential alternative to the graphene-based 2D nanomaterials in biomedical applications. Though the BP's outlook appears promising, its practical applicability is highly challenging. In this review we have discussed the different strategies for synthesis of BP and then briefed its unique properties which renders it a potential platform for the biomedical application. We then discuss the importance of heterogeneous doping on improving the stability of BP against chemical degradation and enhancing its photoelectric properties. Meanwhile, BP-based nanoconjugates, stimuli responsive nanoplatforms, therapeutic, imaging and biosensing platforms are the domains of special and comprehensive interest for versatile biomedical applications of BP. The physicochemical interactions at the nano-bio interface like protein corona formation on the surface on nanoparticles due to interaction with the plasma proteins and others play a crucial role in the biological effects of BP. Hence, we have also discussed the recent studies on interactions between Black phosphorus based nanoconstructs with various biological molecules. Further, it is vital to consider the fact that, though biocompatible, BP-nanomaterials can induce inflammatory responses and exhibit toxicity in dose and time dependant manner. Therefore, we have briefed the biodegradation and toxicological aspects of BP to enlighten the readers about the safety and toxicity of black phosphorous. The future developments of this 2D nanomaterial will not only serve as a boon for oncology, but also functions as a potential nanoplatform for other biomedical applications.
UR - http://www.scopus.com/inward/record.url?scp=85101409396&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85101409396&partnerID=8YFLogxK
U2 - 10.1016/j.ccr.2021.213826
DO - 10.1016/j.ccr.2021.213826
M3 - Review article
AN - SCOPUS:85101409396
SN - 0010-8545
VL - 435
JO - Coordination Chemistry Reviews
JF - Coordination Chemistry Reviews
M1 - 213826
ER -
