TY - JOUR
T1 - Surface engineered bimetallic nanoparticles based therapeutic and imaging platform
T2 - recent advancements and future perspective
AU - Kotha, Rohini
AU - Fernandes, Gasper
AU - Nikam, Ajinkya Nitin
AU - Kulkarni, Sanjay
AU - Pandey, Abhijeet
AU - Pandey, Sureshwar
AU - Mutalik, Srinivas
N1 - Funding Information:
The authors are thankful to (i) Manipal Academy of Higher Education (MAHE), Manipal, India (for Postdoctoral Fellowship) to Dr Abhijeet Pandey and Dr TMA Pai Doctoral Fellowship to Gasper Fernandes, Ajinkya N Nikam and Sanjay Kulkarni. The authors are also thankful to Manipal College of Pharmaceutical Sciences, MAHE, Manipal, India for providing necessary facilities. Authors are also thankful to Biorender.com, a figure making tool.
Publisher Copyright:
© 2020 Institute of Materials, Minerals and Mining.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/11/1
Y1 - 2020/11/1
N2 - The unique physical and chemical properties of monometallic nanoparticles have been comprehensively explored. Analogously, the combination of two metals induces alterations in the system’s electron density, termed as Bimetallic nanoparticles (BMNP’s) were found to be more desirable than monometallic nanoparticles due to improved stability, activity, and selectivity, thus altering the chemical, optical, and electrical properties. In this review, we showcase the importance in the context of biomedical applications. The article sheds light on utilising BMNP’s in the field of theranostics, diagnosis, and therapeutics by focusing on anticancer, antimicrobial and wound healing activity along with the toxicological problems associated with BMNP’s. In conclusion, BMNP’s can be used as a novel therapeutic and diagnostic system to tackle major health concerns.
AB - The unique physical and chemical properties of monometallic nanoparticles have been comprehensively explored. Analogously, the combination of two metals induces alterations in the system’s electron density, termed as Bimetallic nanoparticles (BMNP’s) were found to be more desirable than monometallic nanoparticles due to improved stability, activity, and selectivity, thus altering the chemical, optical, and electrical properties. In this review, we showcase the importance in the context of biomedical applications. The article sheds light on utilising BMNP’s in the field of theranostics, diagnosis, and therapeutics by focusing on anticancer, antimicrobial and wound healing activity along with the toxicological problems associated with BMNP’s. In conclusion, BMNP’s can be used as a novel therapeutic and diagnostic system to tackle major health concerns.
UR - https://www.scopus.com/pages/publications/85093929238
UR - https://www.scopus.com/pages/publications/85093929238#tab=citedBy
U2 - 10.1080/02670836.2020.1832323
DO - 10.1080/02670836.2020.1832323
M3 - Review article
AN - SCOPUS:85093929238
SN - 0267-0836
VL - 36
SP - 1729
EP - 1748
JO - Materials Science and Technology (United Kingdom)
JF - Materials Science and Technology (United Kingdom)
IS - 16
ER -