@article{3f179df0e5a14e21b559c8f20c22d2a1,
title = "Sustained release bi-layered tablets of diltiazem hydrochloride using insoluble matrix system",
abstract = "A study was undertaken to formulate sustained release tablets by utilizing the bi-layer concept. The formulation contained a fast release layer and a sustaining layer. Ethylcellulose and rosin were used as the matrix forming materials. Matrix tablets of diltiazem hydrochloride were formulated using ethylcellulose or rosin as matrix materials in various quantities (%w/w) to study their ability to retard the release and were evaluated for hardness, friability and drug release. In vitro release from the formulation was studied as per the USP XXIII dissolution procedure. The formulations gave an initial burst effect followed by sustained release for 12 h which indicates bimodal release of diltiazem HCl from the matrix tablets. The data obtained were fitted into Higuchi's models. Analysis of n values of Korsmeyer equation indicated that the drug release involved both diffusional and dissolutional mechanisms.",
author = "A.A. Shirwaikar and A. Srinatha",
note = "Cited By :10 Export Date: 10 November 2017 CODEN: IJSID Correspondence Address: Shirwaikar, A. A.; Department of Pharmaceutics, College of Pharmaceutical Sciences, Manipal-576119, India; email: arunshirwaikar@yahoo.co.in References: Cutler, N.R., Archer, S., (1995) J. Clin. Pharmacol, 35, p. 189; Nicaise, J., Neveux, E., (1995) J. Int. Med. Res, 23, p. 244; Echizen, H., Eichelbaum, M., (1986) Clin. Pharmacokinet, 11, p. 425; Swintosky, J., (1960), US Patent No, 2951792; (1989) Trease and Evan's Pharmacognosy, p. 441. , Evans,W.C, Eds, 13th Edn, ELBS, London; Pathak, Y.V., Dorle, A.K., (1985) Eastern Pharmacist, p. 131; Ramani, C.C., Puranik, Dorle, A.K., (1996) Int. J. Pharm, 137, p. 11; Lalla, J.K., Karnik, S.S., Karnik, V.C., (1993) Indian Drugs, 30, p. 405; Indian Pharmacopoeia, 4th Edn., Ministry of Health & Family welfare, New Delhi., 1995, A-50; (1977) Bentley's Text Book of Pharmaceutics, p. 663. , Rawlins, E.A, Eds, 8th Edn, ELBS, London; Krishnaiah, Y.S.R., Patro, S.S., (2001) Pharma times, 33, p. 16; (1981) Pharmaceutical Dosage Forms: Tablets, 2, p. 186. , Lieberman, H.A, Lachman, L and Schwartz, J.B, Eds, Marcel Dekker, Inc. New York; United States Pharmacopoeia., 23rd Edn., United States Pharmacopoeia Convention, Inc., Rockville, MD, 1995, 1791; Salomon, C.J., Bravo, S.A., Lamas, M.A., (2002) J. Pharm. Pharm. Sci, 5, p. 213; Higuchi, T., (1963) J. Pharm. Sci, 52, p. 1145; Catellani, P., Vaona, G., Plazi, P., Colombo, P., (1988) Acta Pharm. Technol, 34, p. 38",
year = "2004",
language = "English",
volume = "66",
pages = "433--437",
journal = "Indian Journal of Pharmaceutical Sciences",
issn = "0250-474X",
publisher = "Medknow Publications and Media Pvt. Ltd",
number = "4",
}