TY - JOUR
T1 - Sustained release bi-layered tablets of diltiazem hydrochloride using insoluble matrix system
AU - Shirwaikar, A.A.
AU - Srinatha, A.
N1 - Cited By :10
Export Date: 10 November 2017
CODEN: IJSID
Correspondence Address: Shirwaikar, A. A.; Department of Pharmaceutics, College of Pharmaceutical Sciences, Manipal-576119, India; email: [email protected]
References: Cutler, N.R., Archer, S., (1995) J. Clin. Pharmacol, 35, p. 189; Nicaise, J., Neveux, E., (1995) J. Int. Med. Res, 23, p. 244; Echizen, H., Eichelbaum, M., (1986) Clin. Pharmacokinet, 11, p. 425; Swintosky, J., (1960), US Patent No, 2951792; (1989) Trease and Evan's Pharmacognosy, p. 441. , Evans,W.C, Eds, 13th Edn, ELBS, London; Pathak, Y.V., Dorle, A.K., (1985) Eastern Pharmacist, p. 131; Ramani, C.C., Puranik, Dorle, A.K., (1996) Int. J. Pharm, 137, p. 11; Lalla, J.K., Karnik, S.S., Karnik, V.C., (1993) Indian Drugs, 30, p. 405; Indian Pharmacopoeia, 4th Edn., Ministry of Health & Family welfare, New Delhi., 1995, A-50; (1977) Bentley's Text Book of Pharmaceutics, p. 663. , Rawlins, E.A, Eds, 8th Edn, ELBS, London; Krishnaiah, Y.S.R., Patro, S.S., (2001) Pharma times, 33, p. 16; (1981) Pharmaceutical Dosage Forms: Tablets, 2, p. 186. , Lieberman, H.A, Lachman, L and Schwartz, J.B, Eds, Marcel Dekker, Inc. New York; United States Pharmacopoeia., 23rd Edn., United States Pharmacopoeia Convention, Inc., Rockville, MD, 1995, 1791; Salomon, C.J., Bravo, S.A., Lamas, M.A., (2002) J. Pharm. Pharm. Sci, 5, p. 213; Higuchi, T., (1963) J. Pharm. Sci, 52, p. 1145; Catellani, P., Vaona, G., Plazi, P., Colombo, P., (1988) Acta Pharm. Technol, 34, p. 38
PY - 2004
Y1 - 2004
N2 - A study was undertaken to formulate sustained release tablets by utilizing the bi-layer concept. The formulation contained a fast release layer and a sustaining layer. Ethylcellulose and rosin were used as the matrix forming materials. Matrix tablets of diltiazem hydrochloride were formulated using ethylcellulose or rosin as matrix materials in various quantities (%w/w) to study their ability to retard the release and were evaluated for hardness, friability and drug release. In vitro release from the formulation was studied as per the USP XXIII dissolution procedure. The formulations gave an initial burst effect followed by sustained release for 12 h which indicates bimodal release of diltiazem HCl from the matrix tablets. The data obtained were fitted into Higuchi's models. Analysis of n values of Korsmeyer equation indicated that the drug release involved both diffusional and dissolutional mechanisms.
AB - A study was undertaken to formulate sustained release tablets by utilizing the bi-layer concept. The formulation contained a fast release layer and a sustaining layer. Ethylcellulose and rosin were used as the matrix forming materials. Matrix tablets of diltiazem hydrochloride were formulated using ethylcellulose or rosin as matrix materials in various quantities (%w/w) to study their ability to retard the release and were evaluated for hardness, friability and drug release. In vitro release from the formulation was studied as per the USP XXIII dissolution procedure. The formulations gave an initial burst effect followed by sustained release for 12 h which indicates bimodal release of diltiazem HCl from the matrix tablets. The data obtained were fitted into Higuchi's models. Analysis of n values of Korsmeyer equation indicated that the drug release involved both diffusional and dissolutional mechanisms.
M3 - Article
SN - 0250-474X
VL - 66
SP - 433
EP - 437
JO - Indian Journal of Pharmaceutical Sciences
JF - Indian Journal of Pharmaceutical Sciences
IS - 4
ER -