TY - JOUR
T1 - Symptomatic severe hypertriglyceridaemia with asparaginase therapy in acute lymphoblastic leukaemia (ALL) and lymphoblastic lymphoma
T2 - Is rechallenging safe?
AU - Lashkari, Harsha Prasada
AU - Lancaster, Donna
AU - Atra, Ayad
AU - Champion, Michael P.
AU - Taj, Mary M.
PY - 2011/12/1
Y1 - 2011/12/1
N2 - Severe hyperlipidaemia with asparaginase therapy is rare. We report six cases, four of which developed significant problems with severe hyperlipidaemia during induction therapy for ALL and lymphoblastic lymphoma. The median triglyceride level was 22.3 mmol/L and the median cholesterol level was 12.3 mmol/L. None of the patients showed signs or symptoms of pancreatitis. Three children were re-exposed with Peg asparaginase, and one with Erwinia asparaginase, without recurrence of hyperlipidaemia or other symptoms. These cases highlight the dilemma in managing such rare cases of symptomatic hypertriglyceridaemia secondary to asparaginase and steroid therapy.
AB - Severe hyperlipidaemia with asparaginase therapy is rare. We report six cases, four of which developed significant problems with severe hyperlipidaemia during induction therapy for ALL and lymphoblastic lymphoma. The median triglyceride level was 22.3 mmol/L and the median cholesterol level was 12.3 mmol/L. None of the patients showed signs or symptoms of pancreatitis. Three children were re-exposed with Peg asparaginase, and one with Erwinia asparaginase, without recurrence of hyperlipidaemia or other symptoms. These cases highlight the dilemma in managing such rare cases of symptomatic hypertriglyceridaemia secondary to asparaginase and steroid therapy.
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U2 - 10.1007/s12185-011-0966-9
DO - 10.1007/s12185-011-0966-9
M3 - Article
C2 - 22057510
AN - SCOPUS:84355161601
SN - 0925-5710
VL - 94
SP - 571
EP - 575
JO - International Journal of Hematology
JF - International Journal of Hematology
IS - 6
ER -