TY - JOUR
T1 - Synergy of gatifloxacin with cefoperazone and cefoperazone-sulbactam against resistant strains of Pseudomonas aeruginosa
AU - Sivagurunathan, N.
AU - Krishnan, S.
AU - Venkat Rao, J.
AU - Nagappa, A.N.
AU - Subrahmanyam, V.M.
AU - Meenashi Vanathi, B.
N1 - Cited By :4
Export Date: 10 November 2017
CODEN: JMMIA
Correspondence Address: Meenashi Vanathi, B.; Department of Pharmaceutical Biotechnology, Shree Devi College of Pharmacy, Airport Road, Kenjar Village, Mangalore, Karnataka 574142, India; email: [email protected]
Chemicals/CAS: cefoperazone, 62893-19-0, 62893-20-3; gatifloxacin, 112811-59-3, 180200-66-2; sulperazon, 92739-15-6; Anti-Bacterial Agents; Cefoperazone, 62893-19-0; Fluoroquinolones; gatifloxacin, 112811-59-3; Sulbactam, 68373-14-8
References: Bajaksouzian, S., Visalli, M.A., Jacobs, M.R., Appelbaum, P.C., Antipneumococcal activities of cefpirome and cefotaxime, alone and in combination with vancomycin and teicoplanin, determined by checkerboard and time-kill methods (1996) Antimicrob Agents Chemother, 40, pp. 1973-1976; Dawis, M.A., Isenberg, H.D., France, K.A., Jenkins, S.G., In vitro activity of gatifloxacin alone and in combination with cefepime, meropenem, piperacillin and gentamicin against multidrug-resistant organisms (2003) J Antimicrob Chemother, 51, pp. 1203-1211; Eliopoulos, G.M., Moellering Jr, R.C., Laboratory methods used to assess the activity of antimicrobial combinations (1991) Antibiotics in Laboratory Medicine, pp. 432-492. , 3rd edn, pp, Edited by V. Lorian. Baltimore, MD: Williams & Wilkins; Fish, D.N., Choi, M.K., Jung, R., Synergic activity of cephalosporins plus fluoroquinolones against Pseudomonas aeruginosa with resistance to one or both drugs (2002) J Antimicrob Chemother, 50, pp. 1045-1049; Gradelski, E., Valera, L., Bonner, D., Fung-Tomc, J., Synergistic activities of gatifloxacin in combination with other antimicrobial agents against Pseudomonas aeruginosa and related species (2001) Antimicrob Agents Chemother, 45, pp. 3220-3222; Mayer, I., Nagy, E., Investigation of the synergic effects of aminoglycoside-fluoroquinolone and third-generation cephalosporin combinations against clinical isolates of Pseudomonas spp (1999) J Antimicrob Chemother, 43, pp. 651-657; CLSI (1999). Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria that Grow Aerobically, 5th edn, approved standard M7-A5. Wayne, PA: Clinical and Laboratory Standards Institute; (2000) Performance Standards for Antimicrobial Disk Susceptibility Test, approved standard M7-A5, , CLSI , Wayne, PA: Clinical and Laboratory Standards Institute; Neu, H.C., Chin, N.X., In vitro activity of the new fluoroquinolone CP-99,219 (1994) Antimicrob Agents Chemother, 38, pp. 2615-2622; Pankey, G.A., Ashcraft, D.S., In vitro synergy of ciprofloxacin and gatifloxacin against ciprofloxacin-resistant Pseudomonas aeruginosa (2005) Antimicrob Agents Chemother, 49, pp. 2959-2964; (2004) Physicians' Desk Reference, , PDR , 58th edn. Montvale, NJ: Thomsons; Rossolini, G.M., Mantengoli, E., Treatment and control of severe infections caused by multiresistant Pseudomonas aeruginosa (2005) Clin Microbiol Infect, 11 (SUPPL. 4), pp. 17-32; Visalli, M.A., Jacobs, M.R., Appelbaum, P.C., Determination of activities of levofloxacin, alone and combined with gentamicin, ceftazidime, cefpirome, and meropenem, against 124 strains of Pseudomonas aeruginosa by checkerboard and time-kill methodology (1998) Antimicrob Agents Chemother, 42, pp. 953-955
PY - 2008
Y1 - 2008
N2 - Chequerboard and time-kill methods were used to compare the in vitro efficacies of the combinations gatifloxacin (GAT) with cefoperazone (CFP) and GAT with cefoperazone-sulbactam (CFP-SUL) against 58 clinical isolates of Pseudomonas aeruginosa. The combinations GAT+CFP and GAT+CFP-SUL were shown to be synergistic for 36.2 and 58.6% of isolates tested, respectively, using the chequerboard method. Time-kill studies with 11 strains showed synergy in 54.5% for the GAT+CFP combination and 72.7% for the GAT+CFP-SUL combination. The agreement between these two methods was found to be 72-81 %. There was a significant difference in synergy between the two combinations tested (P=0.011). © 2008 SGM.
AB - Chequerboard and time-kill methods were used to compare the in vitro efficacies of the combinations gatifloxacin (GAT) with cefoperazone (CFP) and GAT with cefoperazone-sulbactam (CFP-SUL) against 58 clinical isolates of Pseudomonas aeruginosa. The combinations GAT+CFP and GAT+CFP-SUL were shown to be synergistic for 36.2 and 58.6% of isolates tested, respectively, using the chequerboard method. Time-kill studies with 11 strains showed synergy in 54.5% for the GAT+CFP combination and 72.7% for the GAT+CFP-SUL combination. The agreement between these two methods was found to be 72-81 %. There was a significant difference in synergy between the two combinations tested (P=0.011). © 2008 SGM.
U2 - 10.1099/jmm.0.2008/001636-0
DO - 10.1099/jmm.0.2008/001636-0
M3 - Article
SN - 0022-2615
VL - 57
SP - 1514
EP - 1517
JO - Journal of Medical Microbiology
JF - Journal of Medical Microbiology
IS - 12
ER -