Synthesis and α-Amylase Inhibition Studies of Some Coumarin Derivatives

M. Shivaprasad Shetty; H. S. Anil Kumar; N. V. Anil Kumar

doi:10.1007/s11094-018-1853-y

Synthesis and α-Amylase Inhibition Studies of Some Coumarin Derivatives

M. Shivaprasad Shetty, H. S. Anil Kumar, N. V. Anil Kumar

Department of Chemistry, Manipal Institute of Technology, Manipal

Research output: Contribution to journal › Article › peer-review

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Abstract

A series of nine molecules of coumarin hydrazone derivatives have been synthesized. The purpose of this study was to investigate the anti-diabetic activity of synthesized coumarin derivatives by inhibition of α-amylase enzyme isolated from Aspergillus niger microbial strain. The experiment was conducted by taking 5, 10, 50, and 100 μg/mL of each compound and acarbose as a positive control. The tests showed that compounds 3f (IC₅₀ = 49.70 μg/mL), 3g (IC₅₀ = 79.20 μg/mL), and 3i (IC₅₀ = 48.80 μg/mL) as well as reference drug (IC₅₀ = 81.70 μg/mL) exhibited inhibition activity against the enzyme. The synthesized compounds may be helpful in controlling the glucose level as α-amylase is one of the causes of increased sugar level in human body.

Original language	English
Pages (from-to)	526-530
Number of pages	5
Journal	Pharmaceutical Chemistry Journal
Volume	52
Issue number	6
DOIs	https://doi.org/10.1007/s11094-018-1853-y
Publication status	Published - 01-09-2018

All Science Journal Classification (ASJC) codes

Pharmacology
Drug Discovery

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s11094-018-1853-y

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title = "Synthesis and α-Amylase Inhibition Studies of Some Coumarin Derivatives",

abstract = "A series of nine molecules of coumarin hydrazone derivatives have been synthesized. The purpose of this study was to investigate the anti-diabetic activity of synthesized coumarin derivatives by inhibition of α-amylase enzyme isolated from Aspergillus niger microbial strain. The experiment was conducted by taking 5, 10, 50, and 100 μg/mL of each compound and acarbose as a positive control. The tests showed that compounds 3f (IC50 = 49.70 μg/mL), 3g (IC50 = 79.20 μg/mL), and 3i (IC50 = 48.80 μg/mL) as well as reference drug (IC50 = 81.70 μg/mL) exhibited inhibition activity against the enzyme. The synthesized compounds may be helpful in controlling the glucose level as α-amylase is one of the causes of increased sugar level in human body.",

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AB - A series of nine molecules of coumarin hydrazone derivatives have been synthesized. The purpose of this study was to investigate the anti-diabetic activity of synthesized coumarin derivatives by inhibition of α-amylase enzyme isolated from Aspergillus niger microbial strain. The experiment was conducted by taking 5, 10, 50, and 100 μg/mL of each compound and acarbose as a positive control. The tests showed that compounds 3f (IC50 = 49.70 μg/mL), 3g (IC50 = 79.20 μg/mL), and 3i (IC50 = 48.80 μg/mL) as well as reference drug (IC50 = 81.70 μg/mL) exhibited inhibition activity against the enzyme. The synthesized compounds may be helpful in controlling the glucose level as α-amylase is one of the causes of increased sugar level in human body.

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Synthesis and α-Amylase Inhibition Studies of Some Coumarin Derivatives

Abstract

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