Synthesis and anti-inflammatory activity of substituted (E)-4-phenyl-3-buten-2-ones

G. Elias; M.N.A. Rao

doi:10.1016/0223-5234(88)90212-7

Synthesis and anti-inflammatory activity of substituted (E)-4-phenyl-3-buten-2-ones

G. Elias, M.N.A. Rao

Research output: Contribution to journal › Article › peer-review

48 Citations (Scopus)

Abstract

A series of ring substituted 4-phenyl-3-buten-2-ones was synthesized and evaluated for anti-inflammatory activity by carrageenan-induced paw edema in rats. Several compounds showed significant activity, among them, the 4-acetyloxy-3-methoxy derivative was the most active and the 4-methoxy derivatives were the least effective. © 1988.

Original language	Undefined/Unknown
Pages (from-to)	379-380
Number of pages	2
Journal	European Journal of Medicinal Chemistry
Volume	23
Issue number	4
DOIs	https://doi.org/10.1016/0223-5234(88)90212-7
Publication status	Published - 1988
Externally published	Yes

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10.1016/0223-5234(88)90212-7

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Cite this

@article{7d69cccbb1c94c1ba108149621769810,

title = "Synthesis and anti-inflammatory activity of substituted (E)-4-phenyl-3-buten-2-ones",

abstract = "A series of ring substituted 4-phenyl-3-buten-2-ones was synthesized and evaluated for anti-inflammatory activity by carrageenan-induced paw edema in rats. Several compounds showed significant activity, among them, the 4-acetyloxy-3-methoxy derivative was the most active and the 4-methoxy derivatives were the least effective. {\textcopyright} 1988.",

author = "G. Elias and M.N.A. Rao",

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T1 - Synthesis and anti-inflammatory activity of substituted (E)-4-phenyl-3-buten-2-ones

AU - Elias, G.

AU - Rao, M.N.A.

N1 - cited By 42

PY - 1988

Y1 - 1988

N2 - A series of ring substituted 4-phenyl-3-buten-2-ones was synthesized and evaluated for anti-inflammatory activity by carrageenan-induced paw edema in rats. Several compounds showed significant activity, among them, the 4-acetyloxy-3-methoxy derivative was the most active and the 4-methoxy derivatives were the least effective. © 1988.

AB - A series of ring substituted 4-phenyl-3-buten-2-ones was synthesized and evaluated for anti-inflammatory activity by carrageenan-induced paw edema in rats. Several compounds showed significant activity, among them, the 4-acetyloxy-3-methoxy derivative was the most active and the 4-methoxy derivatives were the least effective. © 1988.

U2 - 10.1016/0223-5234(88)90212-7

DO - 10.1016/0223-5234(88)90212-7

M3 - Article

SN - 0223-5234

VL - 23

SP - 379

EP - 380

JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

IS - 4

ER -