Synthesis and antibacterial activity of some 2,3-disubstituted quinazolin-4(3H) ones

V. Dinakaran; H. Unnissa; E. Kalishwari

Synthesis and antibacterial activity of some 2,3-disubstituted quinazolin-4(3H) ones

V. Dinakaran
, H. Unnissa
, E. Kalishwari

Manipal College of Pharmaceutical Sciences, Manipal

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Some new 2,3-disubstituted quinazolin-4-(3H)-ones have been synthesized by the condensation of respective 2-substituted 1,3-benzoxazin-4-ones (4a-b) with different primary amines in equimolar conc. The structures of these compounds have been established on the basis of their elemental, analytical and spectral data. These compounds were tested for invitro antibacterial activity against Staphylococcus aureus (ATCC 9144), Staphylococcus epidermidis (ATCC 155), Micrococcus luteus (ATCC 8341), Klebsiella pneumoniae (ATCC 29665) and Escherichia coli (ATCC 25922).

Original language	English
Pages (from-to)	347-350
Number of pages	4
Journal	Indian Journal of Heterocyclic Chemistry
Volume	17
Issue number	4
Publication status	Published - 2008

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@article{da8d7167a2314dde92778a466c847d3d,

title = "Synthesis and antibacterial activity of some 2,3-disubstituted quinazolin-4(3H) ones",

abstract = "Some new 2,3-disubstituted quinazolin-4-(3H)-ones have been synthesized by the condensation of respective 2-substituted 1,3-benzoxazin-4-ones (4a-b) with different primary amines in equimolar conc. The structures of these compounds have been established on the basis of their elemental, analytical and spectral data. These compounds were tested for invitro antibacterial activity against Staphylococcus aureus (ATCC 9144), Staphylococcus epidermidis (ATCC 155), Micrococcus luteus (ATCC 8341), Klebsiella pneumoniae (ATCC 29665) and Escherichia coli (ATCC 25922).",

author = "V. Dinakaran and H. Unnissa and E. Kalishwari",

note = "Cited By :2 Export Date: 10 November 2017 Correspondence Address: Dinakaran, V.; Department of Pharmaceutical Chemistry, MCOPS, Manipal-576104, India References: Plescia, S., (1992) Farmaco, 47, p. 465; Mekuskiene, Giedrute, Udrenaite, Emilija, Gaidelis, Povilas, Vainilavicius, (1999) Chemia, 10 (3), p. 214; Rivera, I.A., Somanathan, R., Hellberg, L.H., (1998) Synth. commun, 28, p. 2077; Lakhan, R., Singh, R.L., (1988) Farmaco-Ed Sci, 43, p. 7459; Lemura, R., Manabe, H., Tadayaki, S., (1989) Chem. Pharm. Bull, 37, p. 2723; (1989) Chem. Abstr, 111, p. 232719; El-Gaby, (2000) Phosphorus, Sulfur, Silicon Relat. Elem, 156, p. 157; Abdel-Hemide, S.G., El-Hakim, A.E., El-Helby, A.A., (1996) J. Pharm. Sci, 17, p. 35",

year = "2008",

language = "English",

volume = "17",

pages = "347--350",

journal = "Indian Journal of Heterocyclic Chemistry",

issn = "0971-1627",

publisher = "Connect Journals",

number = "4",

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TY - JOUR

T1 - Synthesis and antibacterial activity of some 2,3-disubstituted quinazolin-4(3H) ones

AU - Dinakaran, V.

AU - Unnissa, H.

AU - Kalishwari, E.

N1 - Cited By :2 Export Date: 10 November 2017 Correspondence Address: Dinakaran, V.; Department of Pharmaceutical Chemistry, MCOPS, Manipal-576104, India References: Plescia, S., (1992) Farmaco, 47, p. 465; Mekuskiene, Giedrute, Udrenaite, Emilija, Gaidelis, Povilas, Vainilavicius, (1999) Chemia, 10 (3), p. 214; Rivera, I.A., Somanathan, R., Hellberg, L.H., (1998) Synth. commun, 28, p. 2077; Lakhan, R., Singh, R.L., (1988) Farmaco-Ed Sci, 43, p. 7459; Lemura, R., Manabe, H., Tadayaki, S., (1989) Chem. Pharm. Bull, 37, p. 2723; (1989) Chem. Abstr, 111, p. 232719; El-Gaby, (2000) Phosphorus, Sulfur, Silicon Relat. Elem, 156, p. 157; Abdel-Hemide, S.G., El-Hakim, A.E., El-Helby, A.A., (1996) J. Pharm. Sci, 17, p. 35

PY - 2008

Y1 - 2008

N2 - Some new 2,3-disubstituted quinazolin-4-(3H)-ones have been synthesized by the condensation of respective 2-substituted 1,3-benzoxazin-4-ones (4a-b) with different primary amines in equimolar conc. The structures of these compounds have been established on the basis of their elemental, analytical and spectral data. These compounds were tested for invitro antibacterial activity against Staphylococcus aureus (ATCC 9144), Staphylococcus epidermidis (ATCC 155), Micrococcus luteus (ATCC 8341), Klebsiella pneumoniae (ATCC 29665) and Escherichia coli (ATCC 25922).

AB - Some new 2,3-disubstituted quinazolin-4-(3H)-ones have been synthesized by the condensation of respective 2-substituted 1,3-benzoxazin-4-ones (4a-b) with different primary amines in equimolar conc. The structures of these compounds have been established on the basis of their elemental, analytical and spectral data. These compounds were tested for invitro antibacterial activity against Staphylococcus aureus (ATCC 9144), Staphylococcus epidermidis (ATCC 155), Micrococcus luteus (ATCC 8341), Klebsiella pneumoniae (ATCC 29665) and Escherichia coli (ATCC 25922).

M3 - Article

SN - 0971-1627

VL - 17

SP - 347

EP - 350

JO - Indian Journal of Heterocyclic Chemistry

JF - Indian Journal of Heterocyclic Chemistry

IS - 4

ER -

Synthesis and antibacterial activity of some 2,3-disubstituted quinazolin-4(3H) ones

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