TY - JOUR
T1 - Synthesis and antibacterial screening of few new 5-membered heterocyclic sugar hydrazones
AU - Namratha, B.
AU - Shetty, Nitinkumar S.
AU - Gaonkar, Santosh L.
PY - 2016/5/1
Y1 - 2016/5/1
N2 - Objective: The aim of this study is to synthesize, characterize, and screen some new 5-membered heterocyclic sugar hydrazones for their antibacterial activities. Methods: A library of sugar hydrazones containing 2-benzofuryl, 2-thiophenyl, and 2-pyrrolyl motifs were synthesized. Structures of the newly synthesized compounds were deduced based on spectral data and elemental analyses. Results: Antibacterial activity was screened against Gram-positive and Gram-negative bacterial strains. Results were compared to gentamicin. Compound 6a exhibited most potent antibacterial activity against all the tested strains. Conclusion: 2-benzofuryl derivatives were observed to be good antibacterials.
AB - Objective: The aim of this study is to synthesize, characterize, and screen some new 5-membered heterocyclic sugar hydrazones for their antibacterial activities. Methods: A library of sugar hydrazones containing 2-benzofuryl, 2-thiophenyl, and 2-pyrrolyl motifs were synthesized. Structures of the newly synthesized compounds were deduced based on spectral data and elemental analyses. Results: Antibacterial activity was screened against Gram-positive and Gram-negative bacterial strains. Results were compared to gentamicin. Compound 6a exhibited most potent antibacterial activity against all the tested strains. Conclusion: 2-benzofuryl derivatives were observed to be good antibacterials.
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M3 - Article
AN - SCOPUS:84969185756
SN - 0974-2441
VL - 9
JO - Asian Journal of Pharmaceutical and Clinical Research
JF - Asian Journal of Pharmaceutical and Clinical Research
IS - 3
ER -