Synthesis and antibacterial screening of few new 5-membered heterocyclic sugar hydrazones

Objective: The aim of this study is to synthesize, characterize, and screen some new 5-membered heterocyclic sugar hydrazones for their antibacterial activities. Methods: A library of sugar hydrazones containing 2-benzofuryl, 2-thiophenyl, and 2-pyrrolyl motifs were synthesized. Structures of the newly synthesized compounds were deduced based on spectral data and elemental analyses. Results: Antibacterial activity was screened against Gram-positive and Gram-negative bacterial strains. Results were compared to gentamicin. Compound 6a exhibited most potent antibacterial activity against all the tested strains. Conclusion: 2-benzofuryl derivatives were observed to be good antibacterials.