TY - JOUR
T1 - Synthesis and antibacterial studies of a new series of 1,2-bis(1,3,4- oxadiazol-2-yl)ethanes and 1,2-bis(4-amino-1,2,4-triazol-3-yl)ethanes
AU - Holla, B. Shivararna
AU - Gonsalves, Richard
AU - Shenoy, Shalini
PY - 2000/1/1
Y1 - 2000/1/1
N2 - The acylhydrazones 3, obtained by the treatment of succinic acid dihydrazide 2 with furfural, nitrofurfuraldehydediacetate and substituted arylfurfurals, on oxidative cyclization with bromine in acetic acid yielded 1,2-bis(1,3,4-oxadiazol-2-yl)ethanes 4 which are further converted into 1,2- bis(4-amino-1,2,4-triazol-3-yl)ethanes 5 with hydrazine hydrate. The newly synthesised compounds are characterised by analytical, IR, NMR and mass spectral data. Most of the newly synthesised compounds have been found to be active against both Gram positive and Gram negative bacteria at less than 6 μg/mL concentration. (C) 2000 Editions scientifiques et medicales Elsevier SAS.
AB - The acylhydrazones 3, obtained by the treatment of succinic acid dihydrazide 2 with furfural, nitrofurfuraldehydediacetate and substituted arylfurfurals, on oxidative cyclization with bromine in acetic acid yielded 1,2-bis(1,3,4-oxadiazol-2-yl)ethanes 4 which are further converted into 1,2- bis(4-amino-1,2,4-triazol-3-yl)ethanes 5 with hydrazine hydrate. The newly synthesised compounds are characterised by analytical, IR, NMR and mass spectral data. Most of the newly synthesised compounds have been found to be active against both Gram positive and Gram negative bacteria at less than 6 μg/mL concentration. (C) 2000 Editions scientifiques et medicales Elsevier SAS.
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U2 - 10.1016/S0223-5234(00)00154-9
DO - 10.1016/S0223-5234(00)00154-9
M3 - Article
C2 - 10758288
AN - SCOPUS:0034067253
SN - 0223-5234
VL - 35
SP - 267
EP - 271
JO - European Journal of Medicinal Chemistry
JF - European Journal of Medicinal Chemistry
IS - 2
ER -