Synthesis and anti‐inflammatory activity of 3‐(benzylideneamino)coumarins in rodents

A series of substituted 3‐(benzylideneamino)coumarins was synthesized and evaluated for anti‐inflammatory activity against carrageenan‐induced edema in rats. Halogenated derivatives 4g and 4c, at oral doses of 100 mg/kg, showed 75 and 60% antiedematous activity, respectively (phenylbutazone antiedematous activity, 58%). The analgesic activity of 4g and 4c, based on inhibition of acetic acid‐induced writhing in mice (67 and 62%, respectively, at oral doses of 100 mg/kg) was comparable with that of aspirin (58%). However, these derivatives were devoid of antipyretic activity and showed low activity against adjuvant‐induced arthritis. Copyright © 1992 Wiley‐Liss, Inc., A Wiley Company