@article{2b06cb2970464344a9ec19deae384807,
title = "Synthesis and antimicrobial activity of new 3,5-disubstituted isoxazoles",
abstract = "New 3,5 disubstituted isoxazoles were prepared by the action of hydroxylamine hydrochloride and sodium acetate on 3-{3-[3-(trifluoromethyl) phenoxy/phenoxy]-4-substituted phenyl/phenyl}-1-(4-substitutedphenyl)-2-propene- 1-ones (chalcones) (II). The structures of the synthesized compounds were settled on the basis of spectral data. The antibacterial, antitubercular and antifungal activities of all compounds have been evaluated. Compounds carrying halogen on a-ring showed strong antimicrobial activity. However the titled compounds exhibited moderate antifungal activity. Some compounds exhibited significant activity towards a strain of Mycobacterium tuberculosis H 37Rv.",
author = "S.G. Kini and A.R. Bhat and R. Bhat and N. Narayanaswamy",
note = "Cited By :1 Export Date: 10 November 2017 Correspondence Address: Kini, S. G.; Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal-576104, India References: Omran Fatima, A., Khair, E., (2004) J. Heterocyclic Chem, 41, p. 327; Hansen, T.V., Wu, P., Fokin, V.V., (2005) J. Org. Chem, 70, p. 7761; Bhatt, A., Parekh, H., Parikh, K., Parikh, A.R., (2001) Indian J. chem, 40 B, p. 57; Nagar, D.N., Mehta, T., Shah, V.H., (2003) Indian J. Heterocyclic Chem, 13, p. 173; (1983) Chem. Abstr, 98, p. 16671; Strupezewski, J.T., Allen, R.C., Durm, R.W., (1985) J. Med. Chem, 28, p. 761; Jain, M., Hoon, C., Known (2000) J. Med. Chem, 44, p. 5428; Hsieh, H.K., Tsao, L.T., Wang, J.P., Lin, C.N., (2000) J. Pharm. Pharmacol, 52 (2), p. 63; R.L. White (Jr.) F.L. Wessels, T.J. Schwan and K.O. Ellis, J. Med. Chem., 30 (1987), 763; Meguro, K., Tawada, H., Sugiyama, Y., Fujita, T., Kamamastu, Y., (1986) Chem. Pharm. Bull, 34, p. 2840",
year = "2008",
language = "English",
volume = "17",
pages = "319--322",
journal = "Indian Journal of Heterocyclic Chemistry",
issn = "0971-1627",
publisher = "National Academy of Chemistry",
number = "4",
}
