Synthesis and antimicrobial activity of new 3,5-disubstituted isoxazoles

S.G. Kini; A.R. Bhat; R. Bhat; N. Narayanaswamy

Synthesis and antimicrobial activity of new 3,5-disubstituted isoxazoles

S.G. Kini
, A.R. Bhat
, R. Bhat
, N. Narayanaswamy

Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

New 3,5 disubstituted isoxazoles were prepared by the action of hydroxylamine hydrochloride and sodium acetate on 3-{3-[3-(trifluoromethyl) phenoxy/phenoxy]-4-substituted phenyl/phenyl}-1-(4-substitutedphenyl)-2-propene- 1-ones (chalcones) (II). The structures of the synthesized compounds were settled on the basis of spectral data. The antibacterial, antitubercular and antifungal activities of all compounds have been evaluated. Compounds carrying halogen on a-ring showed strong antimicrobial activity. However the titled compounds exhibited moderate antifungal activity. Some compounds exhibited significant activity towards a strain of Mycobacterium tuberculosis H 37Rv.

Original language	English
Pages (from-to)	319-322
Number of pages	4
Journal	Indian Journal of Heterocyclic Chemistry
Volume	17
Issue number	4
Publication status	Published - 2008

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@article{2b06cb2970464344a9ec19deae384807,

title = "Synthesis and antimicrobial activity of new 3,5-disubstituted isoxazoles",

abstract = "New 3,5 disubstituted isoxazoles were prepared by the action of hydroxylamine hydrochloride and sodium acetate on 3-\{3-[3-(trifluoromethyl) phenoxy/phenoxy]-4-substituted phenyl/phenyl\}-1-(4-substitutedphenyl)-2-propene- 1-ones (chalcones) (II). The structures of the synthesized compounds were settled on the basis of spectral data. The antibacterial, antitubercular and antifungal activities of all compounds have been evaluated. Compounds carrying halogen on a-ring showed strong antimicrobial activity. However the titled compounds exhibited moderate antifungal activity. Some compounds exhibited significant activity towards a strain of Mycobacterium tuberculosis H 37Rv.",

author = "S.G. Kini and A.R. Bhat and R. Bhat and N. Narayanaswamy",

note = "Cited By :1 Export Date: 10 November 2017 Correspondence Address: Kini, S. G.; Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal-576104, India References: Omran Fatima, A., Khair, E., (2004) J. Heterocyclic Chem, 41, p. 327; Hansen, T.V., Wu, P., Fokin, V.V., (2005) J. Org. Chem, 70, p. 7761; Bhatt, A., Parekh, H., Parikh, K., Parikh, A.R., (2001) Indian J. chem, 40 B, p. 57; Nagar, D.N., Mehta, T., Shah, V.H., (2003) Indian J. Heterocyclic Chem, 13, p. 173; (1983) Chem. Abstr, 98, p. 16671; Strupezewski, J.T., Allen, R.C., Durm, R.W., (1985) J. Med. Chem, 28, p. 761; Jain, M., Hoon, C., Known (2000) J. Med. Chem, 44, p. 5428; Hsieh, H.K., Tsao, L.T., Wang, J.P., Lin, C.N., (2000) J. Pharm. Pharmacol, 52 (2), p. 63; R.L. White (Jr.) F.L. Wessels, T.J. Schwan and K.O. Ellis, J. Med. Chem., 30 (1987), 763; Meguro, K., Tawada, H., Sugiyama, Y., Fujita, T., Kamamastu, Y., (1986) Chem. Pharm. Bull, 34, p. 2840",

year = "2008",

language = "English",

volume = "17",

pages = "319--322",

journal = "Indian Journal of Heterocyclic Chemistry",

issn = "0971-1627",

publisher = "Connect Journals",

number = "4",

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TY - JOUR

T1 - Synthesis and antimicrobial activity of new 3,5-disubstituted isoxazoles

AU - Kini, S.G.

AU - Bhat, A.R.

AU - Bhat, R.

AU - Narayanaswamy, N.

N1 - Cited By :1 Export Date: 10 November 2017 Correspondence Address: Kini, S. G.; Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal-576104, India References: Omran Fatima, A., Khair, E., (2004) J. Heterocyclic Chem, 41, p. 327; Hansen, T.V., Wu, P., Fokin, V.V., (2005) J. Org. Chem, 70, p. 7761; Bhatt, A., Parekh, H., Parikh, K., Parikh, A.R., (2001) Indian J. chem, 40 B, p. 57; Nagar, D.N., Mehta, T., Shah, V.H., (2003) Indian J. Heterocyclic Chem, 13, p. 173; (1983) Chem. Abstr, 98, p. 16671; Strupezewski, J.T., Allen, R.C., Durm, R.W., (1985) J. Med. Chem, 28, p. 761; Jain, M., Hoon, C., Known (2000) J. Med. Chem, 44, p. 5428; Hsieh, H.K., Tsao, L.T., Wang, J.P., Lin, C.N., (2000) J. Pharm. Pharmacol, 52 (2), p. 63; R.L. White (Jr.) F.L. Wessels, T.J. Schwan and K.O. Ellis, J. Med. Chem., 30 (1987), 763; Meguro, K., Tawada, H., Sugiyama, Y., Fujita, T., Kamamastu, Y., (1986) Chem. Pharm. Bull, 34, p. 2840

PY - 2008

Y1 - 2008

N2 - New 3,5 disubstituted isoxazoles were prepared by the action of hydroxylamine hydrochloride and sodium acetate on 3-{3-[3-(trifluoromethyl) phenoxy/phenoxy]-4-substituted phenyl/phenyl}-1-(4-substitutedphenyl)-2-propene- 1-ones (chalcones) (II). The structures of the synthesized compounds were settled on the basis of spectral data. The antibacterial, antitubercular and antifungal activities of all compounds have been evaluated. Compounds carrying halogen on a-ring showed strong antimicrobial activity. However the titled compounds exhibited moderate antifungal activity. Some compounds exhibited significant activity towards a strain of Mycobacterium tuberculosis H 37Rv.

AB - New 3,5 disubstituted isoxazoles were prepared by the action of hydroxylamine hydrochloride and sodium acetate on 3-{3-[3-(trifluoromethyl) phenoxy/phenoxy]-4-substituted phenyl/phenyl}-1-(4-substitutedphenyl)-2-propene- 1-ones (chalcones) (II). The structures of the synthesized compounds were settled on the basis of spectral data. The antibacterial, antitubercular and antifungal activities of all compounds have been evaluated. Compounds carrying halogen on a-ring showed strong antimicrobial activity. However the titled compounds exhibited moderate antifungal activity. Some compounds exhibited significant activity towards a strain of Mycobacterium tuberculosis H 37Rv.

M3 - Article

SN - 0971-1627

VL - 17

SP - 319

EP - 322

JO - Indian Journal of Heterocyclic Chemistry

JF - Indian Journal of Heterocyclic Chemistry

IS - 4

ER -

Synthesis and antimicrobial activity of new 3,5-disubstituted isoxazoles

Abstract

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