TY - JOUR
T1 - Synthesis and antimicrobial activity of some novel thienopyrimidines and triazolothienopyrimidines
AU - Shetty, Nitinkumar S.
AU - Lamani, Ravi S.
AU - Khazi, Imtiyaz Ahmed M
PY - 2009/5
Y1 - 2009/5
N2 - Novel tricyclic thienopyrimidines (3, 5, 6, 9, 11, 12) and triazole fused tetracyclic thienopyrimidines (4a-c, 10a-c) were synthesized from precursors 2-amino-6-methyl-4,5,6,7-tetrahydro-1- benzothiophene-3-carbonitrile 1 and 2-amino-7-oxo-4,5,6,7-tetrahydro-1-benzothio-phene-3-carbonitrile 7 respectively. The corresponding precursors were prepared by employing the Gewald reaction. The structures of newly synthesized compounds were characterized by spectral and analytical data. All the compounds were screened for their biological activities. Some of the compounds displayed promising antibacterial and antifungal activities.
AB - Novel tricyclic thienopyrimidines (3, 5, 6, 9, 11, 12) and triazole fused tetracyclic thienopyrimidines (4a-c, 10a-c) were synthesized from precursors 2-amino-6-methyl-4,5,6,7-tetrahydro-1- benzothiophene-3-carbonitrile 1 and 2-amino-7-oxo-4,5,6,7-tetrahydro-1-benzothio-phene-3-carbonitrile 7 respectively. The corresponding precursors were prepared by employing the Gewald reaction. The structures of newly synthesized compounds were characterized by spectral and analytical data. All the compounds were screened for their biological activities. Some of the compounds displayed promising antibacterial and antifungal activities.
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M3 - Article
AN - SCOPUS:67949106560
SN - 0370-0089
VL - 121
SP - 301
EP - 307
JO - Proceedings of the Indian Academy of Sciences - Section A
JF - Proceedings of the Indian Academy of Sciences - Section A
IS - 3
ER -