Synthesis and antitubercular activity of Mannich bases of 2-methyl-3H-quinazolin-4-ones

P. Nandy; M.T. Vishalakshi; A.R. Bhat

Synthesis and antitubercular activity of Mannich bases of 2-methyl-3H-quinazolin-4-ones

P. Nandy
, M.T. Vishalakshi
, A.R. Bhat

Research output: Contribution to journal › Article › peer-review

Abstract

Condensation of 2 with formaldehyde and 2-methyl-3H-quinazolin-4-one 3 yielded Mannich bases 2-methyl-3-[(2-aminomethyl) benzothiazolyl] quinazolin-4-ones 4(a-d). The synthesized compounds were screened for their antitubercular activity against Mycobacterium tuberculosis H37Rv strain and their structures were confirmed by spectral and elemental analysis data.

Original language	English
Pages (from-to)	293-294
Number of pages	2
Journal	Indian Journal of Heterocyclic Chemistry
Volume	15
Issue number	3
Publication status	Published - 2006
Externally published	Yes

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SDG 3 Good Health and Well-being

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@article{851c951db6c04f6c92cdf9a74233341a,

title = "Synthesis and antitubercular activity of Mannich bases of 2-methyl-3H-quinazolin-4-ones",

abstract = "Condensation of 2 with formaldehyde and 2-methyl-3H-quinazolin-4-one 3 yielded Mannich bases 2-methyl-3-[(2-aminomethyl) benzothiazolyl] quinazolin-4-ones 4(a-d). The synthesized compounds were screened for their antitubercular activity against Mycobacterium tuberculosis H37Rv strain and their structures were confirmed by spectral and elemental analysis data.",

author = "P. Nandy and M.T. Vishalakshi and A.R. Bhat",

note = "Cited By :35 Export Date: 10 November 2017 Correspondence Address: Vishalakshi, M.T.; Department of Pharmaceutical Chemistry, College of Pharmaceutical Sciences, Manipal-576 119, India References: Shukla, J.S., Agarwal, V.K., (1985) Indian J. Chem., 24, p. 886; Sengupta, A.K., Gupta, M.M., (1982) Indian J. Chem., 21 B, p. 600; Waisser, K., Gregor, J., Dostal, H., Kune, J., Kubicova, L., Klimeova, V., Kaustova, J., (2001) IL Farmaco, 56 (10), p. 803; Kune, J., Baant, J., Pour, M., Waisser, K., Losarek, M., Janoth, J., (2000) IL Farmaco, 55 (11-12), p. 725; Paranjape, S.D., Bobade, A.S., Khadse, B.G., (2001) Drug. Res., 51 (11), p. 916; Watt, B., Rayner, A., Harris, G., (1996) Mackie \& Mc Cartney Practical Medical Microbiology, p. 331. , Churchill Livigstone, New York",

year = "2006",

language = "English",

volume = "15",

pages = "293--294",

journal = "Indian Journal of Heterocyclic Chemistry",

issn = "0971-1627",

publisher = "Connect Journals",

number = "3",

}

TY - JOUR

T1 - Synthesis and antitubercular activity of Mannich bases of 2-methyl-3H-quinazolin-4-ones

AU - Nandy, P.

AU - Vishalakshi, M.T.

AU - Bhat, A.R.

N1 - Cited By :35 Export Date: 10 November 2017 Correspondence Address: Vishalakshi, M.T.; Department of Pharmaceutical Chemistry, College of Pharmaceutical Sciences, Manipal-576 119, India References: Shukla, J.S., Agarwal, V.K., (1985) Indian J. Chem., 24, p. 886; Sengupta, A.K., Gupta, M.M., (1982) Indian J. Chem., 21 B, p. 600; Waisser, K., Gregor, J., Dostal, H., Kune, J., Kubicova, L., Klimeova, V., Kaustova, J., (2001) IL Farmaco, 56 (10), p. 803; Kune, J., Baant, J., Pour, M., Waisser, K., Losarek, M., Janoth, J., (2000) IL Farmaco, 55 (11-12), p. 725; Paranjape, S.D., Bobade, A.S., Khadse, B.G., (2001) Drug. Res., 51 (11), p. 916; Watt, B., Rayner, A., Harris, G., (1996) Mackie & Mc Cartney Practical Medical Microbiology, p. 331. , Churchill Livigstone, New York

PY - 2006

Y1 - 2006

N2 - Condensation of 2 with formaldehyde and 2-methyl-3H-quinazolin-4-one 3 yielded Mannich bases 2-methyl-3-[(2-aminomethyl) benzothiazolyl] quinazolin-4-ones 4(a-d). The synthesized compounds were screened for their antitubercular activity against Mycobacterium tuberculosis H37Rv strain and their structures were confirmed by spectral and elemental analysis data.

AB - Condensation of 2 with formaldehyde and 2-methyl-3H-quinazolin-4-one 3 yielded Mannich bases 2-methyl-3-[(2-aminomethyl) benzothiazolyl] quinazolin-4-ones 4(a-d). The synthesized compounds were screened for their antitubercular activity against Mycobacterium tuberculosis H37Rv strain and their structures were confirmed by spectral and elemental analysis data.

M3 - Article

SN - 0971-1627

VL - 15

SP - 293

EP - 294

JO - Indian Journal of Heterocyclic Chemistry

JF - Indian Journal of Heterocyclic Chemistry

IS - 3

ER -

Synthesis and antitubercular activity of Mannich bases of 2-methyl-3H-quinazolin-4-ones

Abstract

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