Synthesis and biological activity of some quinazolinone derivatives

N-acetyl-4-nitro anthranilic acid (III), was heated with formamide at 180° for 4 hr, when 7-nitro-2-methyl-4 (3H)-quinazolinone (IV) was obtained in good yields. Mannich bases (Va-o) were obtained when (IV) was reacted with certain amines and other compounds in the presence of formaldehyde under Mannich conditions. The compounds synthesized were screened for antibacterial and some of them for antitubercular activities against S. aureus, B-subtilis (+ve), E. coli. S. typhae, P. Vulgaris (-ve) and human strain of Mycobacterium tuberculosis H37Rv. Four compounds were screened for antiinflammatory activity. Some of the compounds showed promising activities.