Synthesis and biological evaluation of new benzofuranyl isoxazoles as antitubercular, antibacterial and antifungal agents

K. Manna; Y.K. Agarwal; K.K. Srinivasan

Synthesis and biological evaluation of new benzofuranyl isoxazoles as antitubercular, antibacterial and antifungal agents

K. Manna
, Y.K. Agarwal
, K.K. Srinivasan

Manipal College of Pharmaceutical Sciences, Manipal

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Substituted benzofuran chalcones (2a-n) were prepared by the reaction of 2-acetyl benzofuran (1) with different aromatic aldehydes in presence of strong base. Benzofuran chalcones (2a-n) on cyclocondensation with hydroxylamine hydrochloride in presence of sodium acetate, gave various 3-(1-benzofuran-2-yl)- 5-phenylisoxazoles (3a-n). The structure of benzofuran isoxazoles 3a-n have been established on the basis of spectral (IR, 1H NMR, Mass) data. The benzofuran isoxazoles were evaluated for their, antitubercular, antimicrobial and antiinflammatory activities. Some of the compounds have shown promising antitubercular and antibacterial activity.

Original language	English
Pages (from-to)	87-88
Number of pages	2
Journal	Indian Journal of Heterocyclic Chemistry
Volume	18
Issue number	1
Publication status	Published - 2008

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@article{6a9be8bbcb4b48dc962487e3a4b87e20,

title = "Synthesis and biological evaluation of new benzofuranyl isoxazoles as antitubercular, antibacterial and antifungal agents",

abstract = "Substituted benzofuran chalcones (2a-n) were prepared by the reaction of 2-acetyl benzofuran (1) with different aromatic aldehydes in presence of strong base. Benzofuran chalcones (2a-n) on cyclocondensation with hydroxylamine hydrochloride in presence of sodium acetate, gave various 3-(1-benzofuran-2-yl)- 5-phenylisoxazoles (3a-n). The structure of benzofuran isoxazoles 3a-n have been established on the basis of spectral (IR, 1H NMR, Mass) data. The benzofuran isoxazoles were evaluated for their, antitubercular, antimicrobial and antiinflammatory activities. Some of the compounds have shown promising antitubercular and antibacterial activity.",

author = "K. Manna and Y.K. Agarwal and K.K. Srinivasan",

note = "Cited By :4 Export Date: 10 November 2017 Correspondence Address: Manna, K.; Institute of Pharmacy, Nirma University of Science and Technology, Ahmedabad, India References: Zboinska, E., Sztajer, H., Lejezak, B., Kafarski, P., (1990) FEMS Microbiol. Lett, 70, p. 23; Sangapure, S.S., Veeresh, D.H., Yadav, B., (2000) Indian J. Heterocyclic Chem, 10, p. 21; Sangapure, S.S., Veeresh, D.H., Yadav, B., (2000) Indian J. Heterocyclic Chem, 10, p. 21; Rescifina, A., Chiacchio, M.A., Corsaro, A., De Clercq, E., lannazzo, D., Mastino, A., Piperno, A., Valveri, V., (2006) J. Med. Chem, 49, p. 709; Kaffy, J., Pontikis, R., Carrez, D., Croisy, A., Monneret, C., Florent, J.C., (2006) Bioorg Med. Chem, 27, p. 22",

year = "2008",

language = "English",

volume = "18",

pages = "87--88",

journal = "Indian Journal of Heterocyclic Chemistry",

issn = "0971-1627",

publisher = "Connect Journals",

number = "1",

}

TY - JOUR

T1 - Synthesis and biological evaluation of new benzofuranyl isoxazoles as antitubercular, antibacterial and antifungal agents

AU - Manna, K.

AU - Agarwal, Y.K.

AU - Srinivasan, K.K.

N1 - Cited By :4 Export Date: 10 November 2017 Correspondence Address: Manna, K.; Institute of Pharmacy, Nirma University of Science and Technology, Ahmedabad, India References: Zboinska, E., Sztajer, H., Lejezak, B., Kafarski, P., (1990) FEMS Microbiol. Lett, 70, p. 23; Sangapure, S.S., Veeresh, D.H., Yadav, B., (2000) Indian J. Heterocyclic Chem, 10, p. 21; Sangapure, S.S., Veeresh, D.H., Yadav, B., (2000) Indian J. Heterocyclic Chem, 10, p. 21; Rescifina, A., Chiacchio, M.A., Corsaro, A., De Clercq, E., lannazzo, D., Mastino, A., Piperno, A., Valveri, V., (2006) J. Med. Chem, 49, p. 709; Kaffy, J., Pontikis, R., Carrez, D., Croisy, A., Monneret, C., Florent, J.C., (2006) Bioorg Med. Chem, 27, p. 22

PY - 2008

Y1 - 2008

N2 - Substituted benzofuran chalcones (2a-n) were prepared by the reaction of 2-acetyl benzofuran (1) with different aromatic aldehydes in presence of strong base. Benzofuran chalcones (2a-n) on cyclocondensation with hydroxylamine hydrochloride in presence of sodium acetate, gave various 3-(1-benzofuran-2-yl)- 5-phenylisoxazoles (3a-n). The structure of benzofuran isoxazoles 3a-n have been established on the basis of spectral (IR, 1H NMR, Mass) data. The benzofuran isoxazoles were evaluated for their, antitubercular, antimicrobial and antiinflammatory activities. Some of the compounds have shown promising antitubercular and antibacterial activity.

AB - Substituted benzofuran chalcones (2a-n) were prepared by the reaction of 2-acetyl benzofuran (1) with different aromatic aldehydes in presence of strong base. Benzofuran chalcones (2a-n) on cyclocondensation with hydroxylamine hydrochloride in presence of sodium acetate, gave various 3-(1-benzofuran-2-yl)- 5-phenylisoxazoles (3a-n). The structure of benzofuran isoxazoles 3a-n have been established on the basis of spectral (IR, 1H NMR, Mass) data. The benzofuran isoxazoles were evaluated for their, antitubercular, antimicrobial and antiinflammatory activities. Some of the compounds have shown promising antitubercular and antibacterial activity.

M3 - Article

SN - 0971-1627

VL - 18

SP - 87

EP - 88

JO - Indian Journal of Heterocyclic Chemistry

JF - Indian Journal of Heterocyclic Chemistry

IS - 1

ER -

Synthesis and biological evaluation of new benzofuranyl isoxazoles as antitubercular, antibacterial and antifungal agents

Abstract

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