TY - JOUR
T1 - Synthesis and biological evaluation of some novel quinazolones
AU - Jessy, E.
AU - Sambanthan, A.
AU - Joseph, A.
AU - Sridevi, C.
AU - Srinivasan, K.
N1 - Cited By :15
Export Date: 10 November 2017
CODEN: IJSID
Correspondence Address: Jessy, E.; Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical SciencesIndia; email: [email protected]
Chemicals/CAS: carrageenan, 9000-07-1, 9049-05-2, 9061-82-9, 9064-57-7; ciprofloxacin, 85721-33-1; ibuprofen, 15687-27-1, 79261-49-7, 31121-93-4, 527688-20-6
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PY - 2007
Y1 - 2007
N2 - In view of the potent antimicrobial and antiinflammatory activities exhibited by quinazolin-4-(3H)-ones, a series of novel 2, 3-disubstituted-3,1- quinazolin-4-(3H) ones have been synthesized. The synthesized compounds were screened for antibacterial and antiinflammatory activities. Compounds 3a and 3l showed significant antiinflammatory activity comparable to ibuprofen, while the compound 3J showed antibacterial activity comparable to ciprofloxacin.
AB - In view of the potent antimicrobial and antiinflammatory activities exhibited by quinazolin-4-(3H)-ones, a series of novel 2, 3-disubstituted-3,1- quinazolin-4-(3H) ones have been synthesized. The synthesized compounds were screened for antibacterial and antiinflammatory activities. Compounds 3a and 3l showed significant antiinflammatory activity comparable to ibuprofen, while the compound 3J showed antibacterial activity comparable to ciprofloxacin.
M3 - Article
SN - 0250-474X
VL - 69
SP - 476
EP - 478
JO - Indian Journal of Pharmaceutical Sciences
JF - Indian Journal of Pharmaceutical Sciences
IS - 3
ER -