Synthesis and biological evaluation of some Schiff bases of 4-amino-5-(4-methylsulfonyl)benzyl-2,4-dihydro-3H-[1,2,4]-triazole-3-thione

V. Sumangala; Boja Poojary; N. Chidananda; T. Arulmoli; Shalini Shenoy

doi:10.1007/s00044-012-0294-5

Synthesis and biological evaluation of some Schiff bases of 4-amino-5-(4-methylsulfonyl)benzyl-2,4-dihydro-3H-[1,2,4]-triazole-3-thione

V. Sumangala, Boja Poojary, N. Chidananda, T. Arulmoli, Shalini Shenoy

Department of Microbiology, Kasturba Medical College, Mangalore

Research output: Contribution to journal › Article › peer-review

30 Citations (SciVal)

Abstract

The basic nucleus 4-amino-5-[4-(methylsulfonyl)benzyl]-2,4-dihydro-3H-[1,2, 4]-triazole-3-thione was prepared by cyclisation of potassium dithiocarbazinate with hydrazine hydrate using ethanol as solvent under reflux condition. The compound which has been synthesized successfully was subjected to addition reaction with different aldehydes to synthesize Schiff bases. The compounds were confirmed by spectroscopic methods (IR, NMR, and Mass). In order to ascertain the pharmaceutical application, the selective pharmacological screening of the derivatives was carried out according to the standard procedures. The compounds were screened for their cytotoxic activity and antimicrobial activity.

Original language	English
Pages (from-to)	2921-2928
Number of pages	8
Journal	Medicinal Chemistry Research
Volume	22
Issue number	6
DOIs	https://doi.org/10.1007/s00044-012-0294-5
Publication status	Published - 01-06-2013

All Science Journal Classification (ASJC) codes

Pharmacology, Toxicology and Pharmaceutics(all)
Organic Chemistry

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AU - Poojary, Boja

AU - Chidananda, N.

AU - Arulmoli, T.

AU - Shenoy, Shalini

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Synthesis and biological evaluation of some Schiff bases of 4-amino-5-(4-methylsulfonyl)benzyl-2,4-dihydro-3H-[1,2,4]-triazole-3-thione

Abstract

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