Synthesis and biological evaluations of new benzofuran 1,3,5-trisubstituted pyrazoline derivatives of paracetamol as potential antitubercular, antimicrobial agents

Y.K. Agarwal; K. Manna; H. Bhatt; P. Gogai; V.H. Babu; K.K. Srinivasan

Synthesis and biological evaluations of new benzofuran 1,3,5-trisubstituted pyrazoline derivatives of paracetamol as potential antitubercular, antimicrobial agents

Y.K. Agarwal
, K. Manna
, H. Bhatt
, P. Gogai
, V.H. Babu
, K.K. Srinivasan

Research output: Contribution to journal › Article › peer-review

Abstract

Cyclocondensation of benzofuran chalcones (2) with paracetamol hydrazide (5) resulted in the formation of benzofuran-2-pyrazolines (6a-n). Chalcones are synthesized by Claisen-Schmidt condensation involving treatment of 2-acetyl benzofuran (1a) with different aromatic aldehydes. The compounds were evaluated for antitubercular, antimicrobial and antiinflammatory activities.

Original language	English
Pages (from-to)	263-266
Number of pages	4
Journal	Indian Journal of Heterocyclic Chemistry
Volume	16
Issue number	3
Publication status	Published - 2007
Externally published	Yes

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Agarwal, Y. K., Manna, K., Bhatt, H., Gogai, P., Babu, V. H., & Srinivasan, K. K. (2007). Synthesis and biological evaluations of new benzofuran 1,3,5-trisubstituted pyrazoline derivatives of paracetamol as potential antitubercular, antimicrobial agents. Indian Journal of Heterocyclic Chemistry, 16(3), 263-266. https://www.scopus.com/inward/record.uri?eid=2-s2.0-34547273936&partnerID=40&md5=9f7afff8f3d3a860b15f5eee803eb523

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title = "Synthesis and biological evaluations of new benzofuran 1,3,5-trisubstituted pyrazoline derivatives of paracetamol as potential antitubercular, antimicrobial agents",

abstract = "Cyclocondensation of benzofuran chalcones (2) with paracetamol hydrazide (5) resulted in the formation of benzofuran-2-pyrazolines (6a-n). Chalcones are synthesized by Claisen-Schmidt condensation involving treatment of 2-acetyl benzofuran (1a) with different aromatic aldehydes. The compounds were evaluated for antitubercular, antimicrobial and antiinflammatory activities.",

author = "Y.K. Agarwal and K. Manna and H. Bhatt and P. Gogai and V.H. Babu and K.K. Srinivasan",

note = "Cited By :8 Export Date: 10 November 2017 Correspondence Address: Agarwal, Y.K.; Institute of Pharmacy, Nirma University of Science and Technology, Ahmedabad-382 481, India References: Sangapure, S.S., Veeresh, H.D., Yadav, B., (2000) Indian J. Heterocyclic Chem, 10, p. 21; Kumar, N., Sharma, A.K., Garg, R., Yadav, A.K., (2006) Indian J. Chem, 45 B, p. 747; Bharmal, M.F., Kareriya, J.D., Parekh, H.H., (2001) Indian J. Heterocyclic Chem, 10, p. 181; Patel, R.B., Desai, P.S., Desai, R.K., Chikhalia, H.K., (2006) Indian J. Chem, 45 B, p. 773; Kumar, R., Prasad, V.V.S.R., Mayur, Y.C., Kumar, S.S.M., Raju, M.B., (2006) Indian J. Heterocyclic Chem, 15, p. 245",

year = "2007",

language = "English",

volume = "16",

pages = "263--266",

journal = "Indian Journal of Heterocyclic Chemistry",

issn = "0971-1627",

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Agarwal, YK, Manna, K, Bhatt, H, Gogai, P, Babu, VH & Srinivasan, KK 2007, 'Synthesis and biological evaluations of new benzofuran 1,3,5-trisubstituted pyrazoline derivatives of paracetamol as potential antitubercular, antimicrobial agents', Indian Journal of Heterocyclic Chemistry, vol. 16, no. 3, pp. 263-266. <https://www.scopus.com/inward/record.uri?eid=2-s2.0-34547273936&partnerID=40&md5=9f7afff8f3d3a860b15f5eee803eb523>

TY - JOUR

T1 - Synthesis and biological evaluations of new benzofuran 1,3,5-trisubstituted pyrazoline derivatives of paracetamol as potential antitubercular, antimicrobial agents

AU - Agarwal, Y.K.

AU - Manna, K.

AU - Bhatt, H.

AU - Gogai, P.

AU - Babu, V.H.

AU - Srinivasan, K.K.

N1 - Cited By :8 Export Date: 10 November 2017 Correspondence Address: Agarwal, Y.K.; Institute of Pharmacy, Nirma University of Science and Technology, Ahmedabad-382 481, India References: Sangapure, S.S., Veeresh, H.D., Yadav, B., (2000) Indian J. Heterocyclic Chem, 10, p. 21; Kumar, N., Sharma, A.K., Garg, R., Yadav, A.K., (2006) Indian J. Chem, 45 B, p. 747; Bharmal, M.F., Kareriya, J.D., Parekh, H.H., (2001) Indian J. Heterocyclic Chem, 10, p. 181; Patel, R.B., Desai, P.S., Desai, R.K., Chikhalia, H.K., (2006) Indian J. Chem, 45 B, p. 773; Kumar, R., Prasad, V.V.S.R., Mayur, Y.C., Kumar, S.S.M., Raju, M.B., (2006) Indian J. Heterocyclic Chem, 15, p. 245

PY - 2007

Y1 - 2007

N2 - Cyclocondensation of benzofuran chalcones (2) with paracetamol hydrazide (5) resulted in the formation of benzofuran-2-pyrazolines (6a-n). Chalcones are synthesized by Claisen-Schmidt condensation involving treatment of 2-acetyl benzofuran (1a) with different aromatic aldehydes. The compounds were evaluated for antitubercular, antimicrobial and antiinflammatory activities.

AB - Cyclocondensation of benzofuran chalcones (2) with paracetamol hydrazide (5) resulted in the formation of benzofuran-2-pyrazolines (6a-n). Chalcones are synthesized by Claisen-Schmidt condensation involving treatment of 2-acetyl benzofuran (1a) with different aromatic aldehydes. The compounds were evaluated for antitubercular, antimicrobial and antiinflammatory activities.

M3 - Article

SN - 0971-1627

VL - 16

SP - 263

EP - 266

JO - Indian Journal of Heterocyclic Chemistry

JF - Indian Journal of Heterocyclic Chemistry

IS - 3

ER -

Synthesis and biological evaluations of new benzofuran 1,3,5-trisubstituted pyrazoline derivatives of paracetamol as potential antitubercular, antimicrobial agents

Abstract

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