Synthesis and characterization of 2-(4-((1-alkyl or aryl-1H-1,2,3-triazol- 4-yl)methoxy)phenyl)naphtho[1,2-d]oxazoles for protein tyrosine phosphatase 1B inhibitory activity

Sridhar Madabhushi; Narsaiah Chinthala; Abhinav Kanwal; Gagandeep Kaur; Sanjay K. Banerjee

doi:10.1007/s00044-013-0784-0

Synthesis and characterization of 2-(4-((1-alkyl or aryl-1H-1,2,3-triazol- 4-yl)methoxy)phenyl)naphtho[1,2-d]oxazoles for protein tyrosine phosphatase 1B inhibitory activity

Sridhar Madabhushi^*, Narsaiah Chinthala, Abhinav Kanwal, Gagandeep Kaur, Sanjay K. Banerjee

^*Corresponding author for this work

Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal

Research output: Contribution to journal › Article › peer-review

Abstract

2-(4-((1-Alkyl/aryl-1H-1,2,3-triazol-4-yl)methoxy) phenyl)naphtho[1,2-d] were prepared and evaluated as protein tyrosine phosphatase 1B (PTP1B) inhibitors. In this study, two new compounds with potent PTP1B inhibitory activity were identified.

Original language	English
Pages (from-to)	2062-2069
Number of pages	8
Journal	Medicinal Chemistry Research
Volume	23
Issue number	4
DOIs	https://doi.org/10.1007/s00044-013-0784-0
Publication status	Published - 01-01-2014

All Science Journal Classification (ASJC) codes

Pharmacology, Toxicology and Pharmaceutics(all)
Organic Chemistry

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10.1007/s00044-013-0784-0

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title = "Synthesis and characterization of 2-(4-((1-alkyl or aryl-1H-1,2,3-triazol- 4-yl)methoxy)phenyl)naphtho[1,2-d]oxazoles for protein tyrosine phosphatase 1B inhibitory activity",

abstract = "2-(4-((1-Alkyl/aryl-1H-1,2,3-triazol-4-yl)methoxy) phenyl)naphtho[1,2-d] were prepared and evaluated as protein tyrosine phosphatase 1B (PTP1B) inhibitors. In this study, two new compounds with potent PTP1B inhibitory activity were identified.",

author = "Sridhar Madabhushi and Narsaiah Chinthala and Abhinav Kanwal and Gagandeep Kaur and Banerjee, {Sanjay K.}",

year = "2014",

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doi = "10.1007/s00044-013-0784-0",

language = "English",

volume = "23",

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journal = "Medicinal Chemistry Research",

issn = "1054-2523",

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Synthesis and characterization of 2-(4-((1-alkyl or aryl-1H-1,2,3-triazol- 4-yl)methoxy)phenyl)naphtho[1,2-d]oxazoles for protein tyrosine phosphatase 1B inhibitory activity. / Madabhushi, Sridhar; Chinthala, Narsaiah; Kanwal, Abhinav et al.
In: Medicinal Chemistry Research, Vol. 23, No. 4, 01.01.2014, p. 2062-2069.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Synthesis and characterization of 2-(4-((1-alkyl or aryl-1H-1,2,3-triazol- 4-yl)methoxy)phenyl)naphtho[1,2-d]oxazoles for protein tyrosine phosphatase 1B inhibitory activity

AU - Madabhushi, Sridhar

AU - Chinthala, Narsaiah

AU - Kanwal, Abhinav

AU - Kaur, Gagandeep

AU - Banerjee, Sanjay K.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - 2-(4-((1-Alkyl/aryl-1H-1,2,3-triazol-4-yl)methoxy) phenyl)naphtho[1,2-d] were prepared and evaluated as protein tyrosine phosphatase 1B (PTP1B) inhibitors. In this study, two new compounds with potent PTP1B inhibitory activity were identified.

AB - 2-(4-((1-Alkyl/aryl-1H-1,2,3-triazol-4-yl)methoxy) phenyl)naphtho[1,2-d] were prepared and evaluated as protein tyrosine phosphatase 1B (PTP1B) inhibitors. In this study, two new compounds with potent PTP1B inhibitory activity were identified.

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Synthesis and characterization of 2-(4-((1-alkyl or aryl-1H-1,2,3-triazol- 4-yl)methoxy)phenyl)naphtho[1,2-d]oxazoles for protein tyrosine phosphatase 1B inhibitory activity

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