Synthesis and cytotoxic activity of novel pyrazoline derivatives against human lung tumor cell line (A549)

Mohammad Shahar Yar; Anees Ahmad Siddiqui; Mohamed Ashraf Ali; Vedigounder Murugan; Raghu Chandrashekhar

doi:10.1002/jccs.200700014

Synthesis and cytotoxic activity of novel pyrazoline derivatives against human lung tumor cell line (A549)

Mohammad Shahar Yar, Anees Ahmad Siddiqui, Mohamed Ashraf Ali, Vedigounder Murugan, Raghu Chandrashekhar

Department of Pharmaceutical Biotechnology, Manipal College of Pharmaceutical Sciences, Manipal

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

In the present investigation, a series of 5-(-4-(substituted)phenyl)-3-(4- hydroxy-3-methylphenyl)-4,5-dihydro-1H-1-pyrazolyl-2-toluidino methane thione and 5-(substituted)phenyl-3-(4-hydroxy-3-methylphenyl)-4,5-dihydro-1H-1- pyrazolyl-2-methoxy anilino methane thiones were synthesized and were examined against human lung tumor cell line (A549) in vitro using the MTT assay system. Among those tested, 5-(4-flurophenyl)-3-(4-hydroxy-3-methylphenyl)-4,5-dihydro- 1H-1-pyrazolyl-2-toluidino methane thione & 5-(4-chlorophenyl)-3-(4-hydroxy- 3-methylphenyl)-4,5-dihydro-1H-1-pyrazolyl-2-methoxy anilino methane thione showed more potent cytotoxicity against human lung tumor cell line (A549) than the other synthesized compounds.

Original language	English
Pages (from-to)	81-86
Number of pages	6
Journal	Journal of the Chinese Chemical Society
Volume	54
Issue number	1
DOIs	https://doi.org/10.1002/jccs.200700014
Publication status	Published - 01-01-2007

All Science Journal Classification (ASJC) codes

Chemistry(all)

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10.1002/jccs.200700014

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title = "Synthesis and cytotoxic activity of novel pyrazoline derivatives against human lung tumor cell line (A549)",

abstract = "In the present investigation, a series of 5-(-4-(substituted)phenyl)-3-(4- hydroxy-3-methylphenyl)-4,5-dihydro-1H-1-pyrazolyl-2-toluidino methane thione and 5-(substituted)phenyl-3-(4-hydroxy-3-methylphenyl)-4,5-dihydro-1H-1- pyrazolyl-2-methoxy anilino methane thiones were synthesized and were examined against human lung tumor cell line (A549) in vitro using the MTT assay system. Among those tested, 5-(4-flurophenyl)-3-(4-hydroxy-3-methylphenyl)-4,5-dihydro- 1H-1-pyrazolyl-2-toluidino methane thione & 5-(4-chlorophenyl)-3-(4-hydroxy- 3-methylphenyl)-4,5-dihydro-1H-1-pyrazolyl-2-methoxy anilino methane thione showed more potent cytotoxicity against human lung tumor cell line (A549) than the other synthesized compounds.",

author = "Yar, {Mohammad Shahar} and Siddiqui, {Anees Ahmad} and Ali, {Mohamed Ashraf} and Vedigounder Murugan and Raghu Chandrashekhar",

year = "2007",

month = jan,

day = "1",

doi = "10.1002/jccs.200700014",

language = "English",

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journal = "Journal of the Chinese Chemical Society",

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TY - JOUR

T1 - Synthesis and cytotoxic activity of novel pyrazoline derivatives against human lung tumor cell line (A549)

AU - Yar, Mohammad Shahar

AU - Siddiqui, Anees Ahmad

AU - Ali, Mohamed Ashraf

AU - Murugan, Vedigounder

AU - Chandrashekhar, Raghu

PY - 2007/1/1

Y1 - 2007/1/1

N2 - In the present investigation, a series of 5-(-4-(substituted)phenyl)-3-(4- hydroxy-3-methylphenyl)-4,5-dihydro-1H-1-pyrazolyl-2-toluidino methane thione and 5-(substituted)phenyl-3-(4-hydroxy-3-methylphenyl)-4,5-dihydro-1H-1- pyrazolyl-2-methoxy anilino methane thiones were synthesized and were examined against human lung tumor cell line (A549) in vitro using the MTT assay system. Among those tested, 5-(4-flurophenyl)-3-(4-hydroxy-3-methylphenyl)-4,5-dihydro- 1H-1-pyrazolyl-2-toluidino methane thione & 5-(4-chlorophenyl)-3-(4-hydroxy- 3-methylphenyl)-4,5-dihydro-1H-1-pyrazolyl-2-methoxy anilino methane thione showed more potent cytotoxicity against human lung tumor cell line (A549) than the other synthesized compounds.

AB - In the present investigation, a series of 5-(-4-(substituted)phenyl)-3-(4- hydroxy-3-methylphenyl)-4,5-dihydro-1H-1-pyrazolyl-2-toluidino methane thione and 5-(substituted)phenyl-3-(4-hydroxy-3-methylphenyl)-4,5-dihydro-1H-1- pyrazolyl-2-methoxy anilino methane thiones were synthesized and were examined against human lung tumor cell line (A549) in vitro using the MTT assay system. Among those tested, 5-(4-flurophenyl)-3-(4-hydroxy-3-methylphenyl)-4,5-dihydro- 1H-1-pyrazolyl-2-toluidino methane thione & 5-(4-chlorophenyl)-3-(4-hydroxy- 3-methylphenyl)-4,5-dihydro-1H-1-pyrazolyl-2-methoxy anilino methane thione showed more potent cytotoxicity against human lung tumor cell line (A549) than the other synthesized compounds.

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DO - 10.1002/jccs.200700014

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VL - 54

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JF - Journal of the Chinese Chemical Society

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Synthesis and cytotoxic activity of novel pyrazoline derivatives against human lung tumor cell line (A549)

Abstract

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