Synthesis and cytotoxic activity of novel pyrazoline derivatives against human lung tumor cell line (A549)

In the present investigation, a series of 5-(-4-(substituted)phenyl)-3-(4- hydroxy-3-methylphenyl)-4,5-dihydro-1H-1-pyrazolyl-2-toluidino methane thione and 5-(substituted)phenyl-3-(4-hydroxy-3-methylphenyl)-4,5-dihydro-1H-1- pyrazolyl-2-methoxy anilino methane thiones were synthesized and were examined against human lung tumor cell line (A549) in vitro using the MTT assay system. Among those tested, 5-(4-flurophenyl)-3-(4-hydroxy-3-methylphenyl)-4,5-dihydro- 1H-1-pyrazolyl-2-toluidino methane thione & 5-(4-chlorophenyl)-3-(4-hydroxy- 3-methylphenyl)-4,5-dihydro-1H-1-pyrazolyl-2-methoxy anilino methane thione showed more potent cytotoxicity against human lung tumor cell line (A549) than the other synthesized compounds.