@article{46d78c46de454ec58f45ac70b7442348,
title = "Synthesis and evaluation of urea and thiourea derivatives of oxazolidinones as antibacterial agents",
abstract = "Urea and thiourea derivatives of oxazolidinones were synthesized and their inhibitory activity (MIC) was determined on the bacterial strains which includes clinical isolates and quality control organisms. The structure activity relationships were studied and a 3D-QSAR model was built using Genetic Function Approximation. Interestingly found that electron withdrawing groups at the ortho position of the phenyl ring enhances the activity. {\textcopyright} 2007 Pharmaceutical Society of Japan.",
author = "S.K.R. Aaramadaka and M.K. Guha and G. Prabhu and S.G. Kini and M. Vijayan",
note = "Cited By :7 Export Date: 10 November 2017 CODEN: CPBTA Correspondence Address: Aaramadaka, S.K.R.; New Drug Discovery, Orchid Chemicals and Pharmaceuticals Ltd., P. No 476/14, Old Mahabalipuram Rd., Chennai-600019, Tamilnadu, India; email: sunil@scientist.com Chemicals/CAS: linezolid, 165800-03-3; Anti-Bacterial Agents; Oxazolidinones; Thiourea, 62-56-6; Urea, 57-13-6 References: Sullivan, P., Candidate, P.D., (1999) SPAHS Drug Information Service, The University of Mountana, 3, p. 8; Kumar, S.N., Srinivas, D., Khera, S.M., Mamidi, S.V., Rateem, A.M., Das, J., Iqbal, J., Rajagopalan, R., (2002) J. Med. Chem, 45, pp. 3953-3962; Karki, R.G., Kulkarni, V.M., (2001) Bioorg. Med. Chem, 9, pp. 3153-3160; Gregory, W.A., Brittelli, D.R., Wang, J.L.C., Wuonola, A.M., McRipley, J.R., Eustice, C.D., Eberly, S.V., Forbes, M., (1989) J. Med. Chem, 32, pp. 1673-1681; Livermore, D.M., (2001) International Symposium on Antimicrobial Agents and Resistance, pp. 192-200. , Apr. 13; Gregory, W.A., Brittelli, D.R., Wang, J.L., Wuonola, A.M., McRipley, J.R., Eustice, C.D., Eberly, S.V., Forbes, M., (1990) J. Med. Chem, 33, pp. 2569-2578; Barbachyn, M.R., Hutchinson, D.K., Brickner, J.S., Cyanamon, H.M., Kilburn, O.J., Klemans, P.S., Glickman, E.S., Zorenko, E.G., (1996) J. Med. Chem, 39, pp. 680-685; Tucker, J.A., Allwine, D.A., Grega, C.K., Barbachyn, R.M., Klock, L.J., Adamski, L.J., Brickner, J.S., Jensen, M.R., (1998) J. Med. Chem, 41, pp. 3727-3735; Tokoyama, R., Takahashi, Y., Tomita, Y., Tsubouchi, M., Iwasaki, N., Kado, N., Okezak, E., Nagata, O., (2001) Chem. Pharm. Bull, 49, pp. 361-367; Kim, C.S., Chang, S.J., (1997) Korean J. Med. Chem, 7, pp. 145-153; Diekema, D.J., Jones, R.N., (2001) Lancet, 1975-1982; Gadwood R. C., Shinabarger D. A., Ann. Reports Med. Chem., 35, 135-144 (2000); Agarwal, S.K., Guha, M.K., Pandey, S., Satyanarayanan, K., Samuel, M.M., U. S. Patent 0070526 A 1, 2005UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-33846999703&doi=10.1248%2fcpb.55.236&partnerID=40&md5=31fcf1781a67ac0fcf63733a022270ea",
year = "2007",
doi = "10.1248/cpb.55.236",
language = "English",
volume = "55",
pages = "236--240",
journal = "Chemical and Pharmaceutical Bulletin",
issn = "0009-2363",
publisher = "Pharmaceutical Society of Japan",
number = "2",
}