TY - JOUR
T1 - Synthesis and evaluation of urea and thiourea derivatives of oxazolidinones as antibacterial agents
AU - Aaramadaka, S.K.R.
AU - Guha, M.K.
AU - Prabhu, G.
AU - Kini, S.G.
AU - Vijayan, M.
N1 - Cited By :7
Export Date: 10 November 2017
CODEN: CPBTA
Correspondence Address: Aaramadaka, S.K.R.; New Drug Discovery, Orchid Chemicals and Pharmaceuticals Ltd., P. No 476/14, Old Mahabalipuram Rd., Chennai-600019, Tamilnadu, India; email: [email protected]
Chemicals/CAS: linezolid, 165800-03-3; Anti-Bacterial Agents; Oxazolidinones; Thiourea, 62-56-6; Urea, 57-13-6
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PY - 2007
Y1 - 2007
N2 - Urea and thiourea derivatives of oxazolidinones were synthesized and their inhibitory activity (MIC) was determined on the bacterial strains which includes clinical isolates and quality control organisms. The structure activity relationships were studied and a 3D-QSAR model was built using Genetic Function Approximation. Interestingly found that electron withdrawing groups at the ortho position of the phenyl ring enhances the activity. © 2007 Pharmaceutical Society of Japan.
AB - Urea and thiourea derivatives of oxazolidinones were synthesized and their inhibitory activity (MIC) was determined on the bacterial strains which includes clinical isolates and quality control organisms. The structure activity relationships were studied and a 3D-QSAR model was built using Genetic Function Approximation. Interestingly found that electron withdrawing groups at the ortho position of the phenyl ring enhances the activity. © 2007 Pharmaceutical Society of Japan.
U2 - 10.1248/cpb.55.236
DO - 10.1248/cpb.55.236
M3 - Article
SN - 0009-2363
VL - 55
SP - 236
EP - 240
JO - Chemical and Pharmaceutical Bulletin
JF - Chemical and Pharmaceutical Bulletin
IS - 2
ER -