Synthesis and in-vitro antimicrobial activity of 4,6 disubstituted pyrimidines

R. Bhat, G.G. Shenoy

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This paper describes the synthesis and evaluation of antimicrobial profile of new 2-amino 4,6 disubstituted pyrimidines and 2-mercapto 4,6 disubstituted pyrimidines. Our results show that the 2-mercapto 4,6 disubstituted pyrimidines are active against Mycobacterium tuberculosis at 10 μg mL-1, whereas the corresponding 2-amino-4,6 disubstituted pyrimidines are devoid of antitubercular activity. All the compounds were devoid of antibacterial and antifungal activity.
Original languageUndefined/Unknown
Pages (from-to)553-557
Number of pages5
JournalPharmacy and Pharmacology Communications
Issue number12
Publication statusPublished - 2000

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