Synthesis and in-vitro antimicrobial activity of 4,6 disubstituted pyrimidines

R. Bhat; G.G. Shenoy

Synthesis and in-vitro antimicrobial activity of 4,6 disubstituted pyrimidines

R. Bhat
, G.G. Shenoy

Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal

Research output: Contribution to journal › Article › peer-review

Abstract

This paper describes the synthesis and evaluation of antimicrobial profile of new 2-amino 4,6 disubstituted pyrimidines and 2-mercapto 4,6 disubstituted pyrimidines. Our results show that the 2-mercapto 4,6 disubstituted pyrimidines are active against Mycobacterium tuberculosis at 10 μg mL-1, whereas the corresponding 2-amino-4,6 disubstituted pyrimidines are devoid of antitubercular activity. All the compounds were devoid of antibacterial and antifungal activity.

Original language	Undefined/Unknown
Pages (from-to)	553-557
Number of pages	5
Journal	Journal of Pharmacy and Pharmacology
Volume	6
Issue number	12
Publication status	Published - 2000

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0034501039&partnerID=40&md5=10bb4726282e322e989b4dcee55a6be9

Cite this

@article{50dcfe76e2e74d498fbc183a4bdf4cf3,

title = "Synthesis and in-vitro antimicrobial activity of 4,6 disubstituted pyrimidines",

abstract = "This paper describes the synthesis and evaluation of antimicrobial profile of new 2-amino 4,6 disubstituted pyrimidines and 2-mercapto 4,6 disubstituted pyrimidines. Our results show that the 2-mercapto 4,6 disubstituted pyrimidines are active against Mycobacterium tuberculosis at 10 μg mL-1, whereas the corresponding 2-amino-4,6 disubstituted pyrimidines are devoid of antitubercular activity. All the compounds were devoid of antibacterial and antifungal activity.",

author = "R. Bhat and G.G. Shenoy",

note = "cited By 0",

year = "2000",

language = "Undefined/Unknown",

volume = "6",

pages = "553--557",

journal = "Journal of Pharmacy and Pharmacology",

issn = "0022-3573",

publisher = "Oxford University Press",

number = "12",

}

TY - JOUR

T1 - Synthesis and in-vitro antimicrobial activity of 4,6 disubstituted pyrimidines

AU - Bhat, R.

AU - Shenoy, G.G.

N1 - cited By 0

PY - 2000

Y1 - 2000

N2 - This paper describes the synthesis and evaluation of antimicrobial profile of new 2-amino 4,6 disubstituted pyrimidines and 2-mercapto 4,6 disubstituted pyrimidines. Our results show that the 2-mercapto 4,6 disubstituted pyrimidines are active against Mycobacterium tuberculosis at 10 μg mL-1, whereas the corresponding 2-amino-4,6 disubstituted pyrimidines are devoid of antitubercular activity. All the compounds were devoid of antibacterial and antifungal activity.

AB - This paper describes the synthesis and evaluation of antimicrobial profile of new 2-amino 4,6 disubstituted pyrimidines and 2-mercapto 4,6 disubstituted pyrimidines. Our results show that the 2-mercapto 4,6 disubstituted pyrimidines are active against Mycobacterium tuberculosis at 10 μg mL-1, whereas the corresponding 2-amino-4,6 disubstituted pyrimidines are devoid of antitubercular activity. All the compounds were devoid of antibacterial and antifungal activity.

M3 - Article

SN - 0022-3573

VL - 6

SP - 553

EP - 557

JO - Journal of Pharmacy and Pharmacology

JF - Journal of Pharmacy and Pharmacology

IS - 12

ER -