Synthesis and in-vitro antimicrobial activity of 4,6 disubstituted pyrimidines

R. Bhat; G.G. Shenoy

Synthesis and in-vitro antimicrobial activity of 4,6 disubstituted pyrimidines

Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal

Research output: Contribution to journal › Article › peer-review

Abstract

This paper describes the synthesis and evaluation of antimicrobial profile of new 2-amino 4,6 disubstituted pyrimidines and 2-mercapto 4,6 disubstituted pyrimidines. Our results show that the 2-mercapto 4,6 disubstituted pyrimidines are active against Mycobacterium tuberculosis at 10 μg mL-1, whereas the corresponding 2-amino-4,6 disubstituted pyrimidines are devoid of antitubercular activity. All the compounds were devoid of antibacterial and antifungal activity.

Original language	Undefined/Unknown
Pages (from-to)	553-557
Number of pages	5
Journal	Pharmacy and Pharmacology Communications
Volume	6
Issue number	12
Publication status	Published - 2000

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Cite this

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abstract = "This paper describes the synthesis and evaluation of antimicrobial profile of new 2-amino 4,6 disubstituted pyrimidines and 2-mercapto 4,6 disubstituted pyrimidines. Our results show that the 2-mercapto 4,6 disubstituted pyrimidines are active against Mycobacterium tuberculosis at 10 μg mL-1, whereas the corresponding 2-amino-4,6 disubstituted pyrimidines are devoid of antitubercular activity. All the compounds were devoid of antibacterial and antifungal activity.",

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AB - This paper describes the synthesis and evaluation of antimicrobial profile of new 2-amino 4,6 disubstituted pyrimidines and 2-mercapto 4,6 disubstituted pyrimidines. Our results show that the 2-mercapto 4,6 disubstituted pyrimidines are active against Mycobacterium tuberculosis at 10 μg mL-1, whereas the corresponding 2-amino-4,6 disubstituted pyrimidines are devoid of antitubercular activity. All the compounds were devoid of antibacterial and antifungal activity.

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VL - 6

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EP - 557

JO - Pharmacy and Pharmacology Communications

JF - Pharmacy and Pharmacology Communications

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