Synthesis and pharmacological study of 1-acetyl/propyl-3-aryl-5-(5-chloro- 3-methyl-1-phenyl-1H-pyrazol-4-yl)-2-pyrazoline

K.S. Girisha, B. Kalluraya, V. Narayana, Padmashree [Unknown]

Research output: Contribution to journalArticlepeer-review

82 Citations (Scopus)


A series of 1-acetyl/propyl-3-aryl-5-(5-chloro-3-methyl-1-phenyl-1H- pyrazol-4-yl)-2-pyrazolines were synthesized in one step by condensing suitably substituted propenones, hydrazine and acetic/propionic acid. The newly synthesized pyrazolines were characterized by analytical and spectral data. The new compounds were screened for analgesic and anti-inflammatory activity and most of them showed good activity comparable with that of standard drugs Pentazocin and Diclofinac sodium respectively. © 2010 Elsevier Masson SAS. All rights reserved.
Original languageEnglish
Pages (from-to)4640-4644
Number of pages5
JournalEuropean Journal of Medicinal Chemistry
Issue number10
Publication statusPublished - 2010


Dive into the research topics of 'Synthesis and pharmacological study of 1-acetyl/propyl-3-aryl-5-(5-chloro- 3-methyl-1-phenyl-1H-pyrazol-4-yl)-2-pyrazoline'. Together they form a unique fingerprint.

Cite this