TY - JOUR
T1 - Synthesis and pharmacological study of 1-acetyl/propyl-3-aryl-5-(5-chloro- 3-methyl-1-phenyl-1H-pyrazol-4-yl)-2-pyrazoline
AU - Girisha, K.S.
AU - Kalluraya, B.
AU - Narayana, V.
AU - [Unknown], Padmashree
N1 - Cited By :60
Export Date: 26 November 2017
CODEN: EJMCA
Correspondence Address: Kalluraya, B.; Department of Studies in Chemistry, Mangalore University, Mangalagangotri 574 199, Karnataka, India; email: [email protected]
Chemicals/CAS: diclofenac, 15307-79-6, 15307-86-5; hydrazine, 10217-52-4, 13775-80-9, 18500-32-8, 302-01-2, 7803-57-8; pentazocine, 359-83-1, 64024-15-3; Analgesics; Anti-Inflammatory Agents; Pyrazoles
References: Patel, M.V., Bell, R., Majest, S., Henry, R., Kolasa, T., (2004) J. Org. Chem., 69, pp. 7058-7065; Damljanović, I., Vukićević, M., Radulović, N., Palić, R., Ellmerer, E., Ratković, Z., Joksović, M.D., Vukićević, R.D., (2009) Bioorg. Med. Chem. Lett., 19, pp. 1093-1096; Sharma, P.K., Kumar, S., Kumar, P., Kaushik, P., Kaushik, D., Dhingra, Y., Aneja, K.R., (2010) Eur. J. Med. Chem., 45, pp. 2650-2655; Rostom, S.A.F., Shalaby, M.A., El-Demellawy, M.A., (2003) Eur. J. Med. Chem., 38, pp. 959-974; Ghorab, M.M., Ragab, F.A., Alqasoumi, S.I., Alafeefy, A.M., Aboulmagd, S.A., (2010) Eur. J. Med. Chem., 45, pp. 171-178; Amnekar, N.D., Bhusari, K.P., (2010) Eur. J. Med. Chem., 45, pp. 149-159; Yeu, J.P., Yeh, J.T., Chen, T.Y., Uang, B.J., (2001) Synthesis, 12, p. 1775; Levai, A., (2005) Arkivok, 9, pp. 344-352; Shaharyar, M., Siddique, A.A., Ali, M.A., Sriram, D., Yogeeshwari, P., (2006) Bioorg. Med. Chem. Lett., 16, pp. 3947-3949; Rathish, I.G., Javed, K., Ahmad, S., Bano, S., Alam, M.S., Pillai, K.K., Singh, S., Bagchi, V., (2009) Bioorg. Med. Chem. Lett., 19, pp. 255-258; Bawane, B.S., Konda, S.G., Mandwad, G.G., Shaikh, B.M., (2010) Eur. J. Med. Chem., 45, pp. 171-178; Gulhan, T.H., Pierre, C., Fatma, S.K., Kevser, E., (2000) Eur. J. Med. Chem., 35 (6), pp. 635-641; Fischer, E., Knovenagel, O., (1887) Ann. Chem., 239, p. 194; Sathish Rai, N., Kalluraya, B., Lingappa, B., Shaenoy, S., Puranic, V.G., (2008) Eur. J. Med. Chem., 43, pp. 1715-1720; Kalluraya, B., Gunaga, P., Ananda, K., (1999) Indian J. Chem., 38, pp. 1295-1298; Sathish Rai, N., Kalluraya, B., (2007) Indian J. Chem., 46, pp. 375-378; Kulakarni, S.K., (1999) Hand Book of Experimental Pharmacology, , third ed. Vallabha Publications; Distasi, L.C., Costa, M., Mendacolli, S.J.L., Kirzawa, M., Games, C., Trolin, G., (1988) J. Ethnopharmacol., 24, p. 205
PY - 2010
Y1 - 2010
N2 - A series of 1-acetyl/propyl-3-aryl-5-(5-chloro-3-methyl-1-phenyl-1H- pyrazol-4-yl)-2-pyrazolines were synthesized in one step by condensing suitably substituted propenones, hydrazine and acetic/propionic acid. The newly synthesized pyrazolines were characterized by analytical and spectral data. The new compounds were screened for analgesic and anti-inflammatory activity and most of them showed good activity comparable with that of standard drugs Pentazocin and Diclofinac sodium respectively. © 2010 Elsevier Masson SAS. All rights reserved.
AB - A series of 1-acetyl/propyl-3-aryl-5-(5-chloro-3-methyl-1-phenyl-1H- pyrazol-4-yl)-2-pyrazolines were synthesized in one step by condensing suitably substituted propenones, hydrazine and acetic/propionic acid. The newly synthesized pyrazolines were characterized by analytical and spectral data. The new compounds were screened for analgesic and anti-inflammatory activity and most of them showed good activity comparable with that of standard drugs Pentazocin and Diclofinac sodium respectively. © 2010 Elsevier Masson SAS. All rights reserved.
U2 - 10.1016/j.ejmech.2010.07.032
DO - 10.1016/j.ejmech.2010.07.032
M3 - Article
SN - 0223-5234
VL - 45
SP - 4640
EP - 4644
JO - European Journal of Medicinal Chemistry
JF - European Journal of Medicinal Chemistry
IS - 10
ER -