TY - JOUR
T1 - Synthesis, anti-proliferative and genotoxicity studies of 6-chloro-5-(2-substituted-ethyl)-1,3-dihydro-2 H-indol-2-ones and 6-chloro-5-(2-chloroethyl)-3-(alkyl/ary-2-ylidene)indolin-2-ones
AU - Meti, Gangadhar Y.
AU - Kamble, Atulkumar A.
AU - Kamble, Ravindra R.
AU - Somagond, Shilpa M.
AU - Devarajegowda, H. C.
AU - Kumari, Sandhya
AU - Kalthur, Guruprasad
AU - Adiga, Satish K.
PY - 2016/10/4
Y1 - 2016/10/4
N2 - A series of 6-chloro-5-(2-substituted-ethyl)-1,3-dihydro-2H-indol-2-ones (3a-h) and 6-chloro-5-(2-chloroethyl)-3-(alkyl/aryl-2-ylidene)indolin-2-ones (5i-x) were synthesized. Compounds 3a-e, 5i-l and 5q-r were selected by NIH, USA for in vitro anti-proliferative screening. Based on the impressive growth inhibitory (GI %) effect by the compounds 3a-b and 3e which showed growth inhibition in the range 1.22-76.30%, 2.85-76.03% and 10.98-82.05% respectively at 10ĝ'5 concentration, these compounds were further analyzed for anti-proliferative activity at 5 dose concentration and genotoxicity.
AB - A series of 6-chloro-5-(2-substituted-ethyl)-1,3-dihydro-2H-indol-2-ones (3a-h) and 6-chloro-5-(2-chloroethyl)-3-(alkyl/aryl-2-ylidene)indolin-2-ones (5i-x) were synthesized. Compounds 3a-e, 5i-l and 5q-r were selected by NIH, USA for in vitro anti-proliferative screening. Based on the impressive growth inhibitory (GI %) effect by the compounds 3a-b and 3e which showed growth inhibition in the range 1.22-76.30%, 2.85-76.03% and 10.98-82.05% respectively at 10ĝ'5 concentration, these compounds were further analyzed for anti-proliferative activity at 5 dose concentration and genotoxicity.
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U2 - 10.1016/j.ejmech.2016.05.028
DO - 10.1016/j.ejmech.2016.05.028
M3 - Article
C2 - 27240276
AN - SCOPUS:84971330880
SN - 0223-5234
VL - 121
SP - 221
EP - 231
JO - CHIM.THER.
JF - CHIM.THER.
ER -