TY - JOUR
T1 - Synthesis, antiinflammatory and antibacterial activity of novel indolyl-isoxazoles
AU - Panda, S.S.
AU - Chowdary, P.V.R.
AU - Jayashree, B.S.
N1 - Cited By :17
Export Date: 10 November 2017
CODEN: IJSID
Correspondence Address: Panda, S. S.; Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, MAHE Manipal-576 104, India; email: [email protected]
Chemicals/CAS: acetic acid, 127-08-2, 127-09-3, 64-19-7, 71-50-1; carrageenan, 9000-07-1, 9049-05-2, 9061-82-9, 9064-57-7; ciprofloxacin, 85721-33-1; hydroxylamine, 7803-49-8; ibuprofen, 15687-27-1
References: Jung, H.K., Doddareddya, M.R., Cha, J.H., Rhim, H., Cho, Y.S., Koh, H.Y., Synthesis and biological evaluation of novel T-type Ca2+ channel blockers (2004) Bioorg Med Chem, 12, pp. 3965-3970; Popat, K.H., Nirmavat, K.S., Kachhadia, V.V., Joshi, H.S., Synthesis and biological activity of 3-aryl-5-(3'-bromo/chlorophenyl) isoxazoles (2003) J Indian Chem Soc, 80, pp. 707-708; Norman, B.H., Lander, P.A., Gruber, J.M., Kroin, J.S., Cyclohexyl-linked tricyclic isoxazoles are potent and selective modulators of the multidrug resistance protein (MRP1) (2005) Bioorg Med Chem Lett, 15, pp. 5526-5530; Raman, K., Pandey, B.R., Barthwal, J.P., Parmar, S.S., Antiinflammatory and antiproteolytic properties of 1,3-disubstituted-5- (2-arylindol-3-yl)-2- pyrazolines (1980) Eur J Med Chem Chem Ther, 15, pp. 567-569; Kumar, A., Sinha, J.N., Bhargava, K.P., Shanker, K., Synthesis of 1-acetyl- 5-aryl-3-[ortho-(3-chloro-2-indol-3-yl-4-oxo-1- azetidinyl)phenyl]2- pyrazolines (1984) Indian J Chem, 23 B, pp. 589-591; Gupta, D.P., Kumar, P., Ahmad, S., Shanker, K., Synthesis, antiacetylcholinesterase, and anthelmintic activities of newer indolyl derivatives (1990) Indian J Chem, 29 B, pp. 194-196; Lather, V., Chowdary, P.V.R., Synthesis and antimicrobial activity of N1-(arylidine hydrazidomethyl)-indoles,2-(substitutedaryl)-3-(N1- indolylacetamidyl)-4-oxo- thiazolidines and 5-benzylidine derivatives of thiazolidinones (2003) Indian J Pharm Sci, 65, pp. 576-579; Gadaginamath, G.S., Shyadligeri, A.S., Kavali, R.R., Chemoselectivity of indoledicarboxylates towards hydrazine hydrate: Part III- synthesis and antimicrobial activity of novel 4-thiazolidinonylindoles (1999) Indian J Chem, 38 B, pp. 156-159; Renukadevi, P., Biradar, J.S., Synthesis and antimicrobial activity of 3,5-disubstituted-2-[1'-phenyl- 5'-thioalkyl-s-triazol-2'-yl]indoles and 3,5-disubstituted-2-[1'-substituted aminomethyl-4'-phenyl-5',4'- phenyl-5'(4'H)-thion-s-triazol-3-yl]indoles (1999) Indian J Heterocycl Chem, 9, pp. 107-112; Panda, S.S., Chowdary, P.V., Synthesis of novel indolyl-pyrimidine antiinflammatory, antioxidant and antibacterial agents (2008) Indian J Pharm Sci, 70, pp. 208-215; Winter, C.A., Risley, E.A., Nuss, G.W., Carrageenin-induced edema in hind paw of the rat as an assay for antiiflammatory drugs (1962) Proc Soc Expt Biol, 111, pp. 544-547; Clarke, G.M., Cooke, D., (1998) A Basic Course in Statistics, pp. 520-546. , 4th ed. London: Arnold; Kavanagh, F., (1963) Analytical Microbiology, pp. 313-346. , New York Academic Press
PY - 2009
Y1 - 2009
N2 - Chalcones were synthesized by reacting indole-3-aldehyde, prepared by Vilsemeir Haack reaction with 4-substituted acetophenone in ethanolic KOH solution. These chalcones were immediately reacted with hydroxylamine hydrochloride in presence of glacial acetic acid as reagent to obtain the corresponding isoxazole derivatives. The synthesized heterocycles were characterized on the basis of physical, chemical tests and spectroscopic data. These compounds were tested for the acute antiinflammatory activity and antibacterial activity using carrageenan-induced rat paw edema method and cup-plate method, respectively.
AB - Chalcones were synthesized by reacting indole-3-aldehyde, prepared by Vilsemeir Haack reaction with 4-substituted acetophenone in ethanolic KOH solution. These chalcones were immediately reacted with hydroxylamine hydrochloride in presence of glacial acetic acid as reagent to obtain the corresponding isoxazole derivatives. The synthesized heterocycles were characterized on the basis of physical, chemical tests and spectroscopic data. These compounds were tested for the acute antiinflammatory activity and antibacterial activity using carrageenan-induced rat paw edema method and cup-plate method, respectively.
U2 - 10.4103/0250-474X.59554
DO - 10.4103/0250-474X.59554
M3 - Article
SN - 0250-474X
VL - 71
SP - 684
EP - 687
JO - Indian Journal of Pharmaceutical Sciences
JF - Indian Journal of Pharmaceutical Sciences
IS - 6
ER -