Synthesis, antioxidant and anticancer activity of new quinoline-[1, 2, 4]-triazole hybrids

Hemant Hegde; Santosh L. Gaonkar; Naveen P. Badiger; Nitinkumar S. Shetty

doi:10.31788/RJC.2020.1335669

Synthesis, antioxidant and anticancer activity of new quinoline-[1, 2, 4]-triazole hybrids

Hemant Hegde, Santosh L. Gaonkar, Naveen P. Badiger, Nitinkumar S. Shetty

Department of Chemistry, Manipal Institute of Technology, Manipal

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

A set of quinoline coupled triazole derivatives was synthesized using substituted quinoline hydrazide and isothiocyanate derivatives. The structures of the synthesized molecules were confirmed using spectral techniques like FTIR,¹H &¹³C NMR spectroscopy. Novel triazole thione derivatives were subjected to anticancer and antioxidant activity. The studies revealed the moderate anticancer activity of the molecules but have shown potent antioxidant activity.

Original language	English
Pages (from-to)	1744-1749
Number of pages	6
Journal	Rasayan Journal of Chemistry
Volume	13
Issue number	3
DOIs	https://doi.org/10.31788/RJC.2020.1335669
Publication status	Published - 01-07-2020

All Science Journal Classification (ASJC) codes

Chemistry(all)
Biochemistry
Chemical Engineering(all)
Energy(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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AU - Shetty, Nitinkumar S.

PY - 2020/7/1

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N2 - A set of quinoline coupled triazole derivatives was synthesized using substituted quinoline hydrazide and isothiocyanate derivatives. The structures of the synthesized molecules were confirmed using spectral techniques like FTIR,1H &13C NMR spectroscopy. Novel triazole thione derivatives were subjected to anticancer and antioxidant activity. The studies revealed the moderate anticancer activity of the molecules but have shown potent antioxidant activity.

AB - A set of quinoline coupled triazole derivatives was synthesized using substituted quinoline hydrazide and isothiocyanate derivatives. The structures of the synthesized molecules were confirmed using spectral techniques like FTIR,1H &13C NMR spectroscopy. Novel triazole thione derivatives were subjected to anticancer and antioxidant activity. The studies revealed the moderate anticancer activity of the molecules but have shown potent antioxidant activity.

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Synthesis, antioxidant and anticancer activity of new quinoline-[1, 2, 4]-triazole hybrids

Abstract

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