Abstract
In the present study, a series of novel substituted pyrazole chalcones and pyrazole oximes (CF 1-15) were synthesized and characterized. Logp values were determined to assess their hydrophobicity. MTT (methyl tetrazolium) assay was performed on A-549 (lung cancer) cell lines. The MTT assay results showed the effect of various substituents on the pyrazole template that could influence their cytotoxic effect. Out of the 15 compounds screened against A-549 cell lines, the compound CF-6 showed appreciable cytotoxicity against the standard doxorubicin.
| Original language | English |
|---|---|
| Pages (from-to) | 2162-2166 |
| Number of pages | 5 |
| Journal | Research Journal of Pharmacy and Technology |
| Volume | 14 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 04-2021 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
All Science Journal Classification (ASJC) codes
- Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
- Pharmacology (medical)
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