Synthesis, characterization and antimicrobial activity of 7-Amino-2-Styrylchromones

Amita S. Rao; Lalitha Simon; K. K. Srinivasan; K. L. Shobha; B. C. Ganesh Maiya

Synthesis, characterization and antimicrobial activity of 7-Amino-2-Styrylchromones

Amita S. Rao, Lalitha Simon^*, K. K. Srinivasan, K. L. Shobha, B. C. Ganesh Maiya

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Nine derivatives of 7-Amino-2-Styrylchromones (3a-i) were synthesized and characterized. These compounds were examined for their antibacterial activity against the bacterial strains Klebsiella pneumonia, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and antifungal activity against Candida albicans. Klebsiella pneumoniae was found to be resistant to multiple antibiotics such as ampicillin, amoxicillin/ clavulanic acid, gentamycin, amikacin, levofloxacin, imipenem, cefazolin and cefepime. However all the test compounds(3a-i) showed good activity against Klebsiella pneumoniae at 12.5μg /mL concentration. Compound 3dat12.5μg /mL concentration displayed a zone of inhibition of 25mm against Staphylococcus aureus.

Original language	English
Pages (from-to)	157-160
Number of pages	4
Journal	Der Pharma Chemica
Volume	8
Issue number	7
Publication status	Published - 2016

All Science Journal Classification (ASJC) codes

General Chemistry

Cite this

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title = "Synthesis, characterization and antimicrobial activity of 7-Amino-2-Styrylchromones",

abstract = "Nine derivatives of 7-Amino-2-Styrylchromones (3a-i) were synthesized and characterized. These compounds were examined for their antibacterial activity against the bacterial strains Klebsiella pneumonia, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and antifungal activity against Candida albicans. Klebsiella pneumoniae was found to be resistant to multiple antibiotics such as ampicillin, amoxicillin/ clavulanic acid, gentamycin, amikacin, levofloxacin, imipenem, cefazolin and cefepime. However all the test compounds(3a-i) showed good activity against Klebsiella pneumoniae at 12.5μg /mL concentration. Compound 3dat12.5μg /mL concentration displayed a zone of inhibition of 25mm against Staphylococcus aureus.",

author = "Rao, {Amita S.} and Lalitha Simon and Srinivasan, {K. K.} and Shobha, {K. L.} and {Ganesh Maiya}, {B. C.}",

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language = "English",

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pages = "157--160",

journal = "Der Pharma Chemica",

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T1 - Synthesis, characterization and antimicrobial activity of 7-Amino-2-Styrylchromones

AU - Rao, Amita S.

AU - Simon, Lalitha

AU - Srinivasan, K. K.

AU - Shobha, K. L.

AU - Ganesh Maiya, B. C.

PY - 2016

Y1 - 2016

N2 - Nine derivatives of 7-Amino-2-Styrylchromones (3a-i) were synthesized and characterized. These compounds were examined for their antibacterial activity against the bacterial strains Klebsiella pneumonia, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and antifungal activity against Candida albicans. Klebsiella pneumoniae was found to be resistant to multiple antibiotics such as ampicillin, amoxicillin/ clavulanic acid, gentamycin, amikacin, levofloxacin, imipenem, cefazolin and cefepime. However all the test compounds(3a-i) showed good activity against Klebsiella pneumoniae at 12.5μg /mL concentration. Compound 3dat12.5μg /mL concentration displayed a zone of inhibition of 25mm against Staphylococcus aureus.

AB - Nine derivatives of 7-Amino-2-Styrylchromones (3a-i) were synthesized and characterized. These compounds were examined for their antibacterial activity against the bacterial strains Klebsiella pneumonia, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and antifungal activity against Candida albicans. Klebsiella pneumoniae was found to be resistant to multiple antibiotics such as ampicillin, amoxicillin/ clavulanic acid, gentamycin, amikacin, levofloxacin, imipenem, cefazolin and cefepime. However all the test compounds(3a-i) showed good activity against Klebsiella pneumoniae at 12.5μg /mL concentration. Compound 3dat12.5μg /mL concentration displayed a zone of inhibition of 25mm against Staphylococcus aureus.

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M3 - Article

AN - SCOPUS:84973652802

SN - 0975-413X

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JO - Der Pharma Chemica

JF - Der Pharma Chemica

IS - 7

ER -

Synthesis, characterization and antimicrobial activity of 7-Amino-2-Styrylchromones

Abstract

All Science Journal Classification (ASJC) codes

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