Synthesis, characterization, and antimicrobial studies of some quinolines containing 1,3-thiazines

Janardhana Nayak, K. S. Girisha, Balakrishna Kalluraya, Shalini Shenoy

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


6/8-Substituted-2-chloroquinoline-3-carboxylic acids, upon reaction with 3-(p-substituted aryl)-4H-5-mercapto-1,2,4-triazoles in the presence of sodium acetate and an acetic anhydride medium, afforded a novel series of 2-(p-substituted aryl)-s-triazolo[5,1-b]-6/8-substituted quinolino [1,3] thiazin-9(H)-ones. The structures of the new compounds were elucidated by IR, 1H NMR, and mass spectral studies. All the newly synthesized compounds have been screened for their antibacterial and antifungal activities. Most of them showed significant activity comparable with that of the standards Furacin and Flucanazol.

Original languageEnglish
Pages (from-to)2697-2703
Number of pages7
JournalPhosphorus, Sulfur and Silicon and the Related Elements
Issue number10
Publication statusPublished - 01-10-2009

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Organic Chemistry
  • Inorganic Chemistry


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