TY - JOUR
T1 - Synthesis, characterization, and antimicrobial studies of some quinolines containing 1,3-thiazines
AU - Nayak, Janardhana
AU - Girisha, K. S.
AU - Kalluraya, Balakrishna
AU - Shenoy, Shalini
PY - 2009/10/1
Y1 - 2009/10/1
N2 - 6/8-Substituted-2-chloroquinoline-3-carboxylic acids, upon reaction with 3-(p-substituted aryl)-4H-5-mercapto-1,2,4-triazoles in the presence of sodium acetate and an acetic anhydride medium, afforded a novel series of 2-(p-substituted aryl)-s-triazolo[5,1-b]-6/8-substituted quinolino [1,3] thiazin-9(H)-ones. The structures of the new compounds were elucidated by IR, 1H NMR, and mass spectral studies. All the newly synthesized compounds have been screened for their antibacterial and antifungal activities. Most of them showed significant activity comparable with that of the standards Furacin and Flucanazol.
AB - 6/8-Substituted-2-chloroquinoline-3-carboxylic acids, upon reaction with 3-(p-substituted aryl)-4H-5-mercapto-1,2,4-triazoles in the presence of sodium acetate and an acetic anhydride medium, afforded a novel series of 2-(p-substituted aryl)-s-triazolo[5,1-b]-6/8-substituted quinolino [1,3] thiazin-9(H)-ones. The structures of the new compounds were elucidated by IR, 1H NMR, and mass spectral studies. All the newly synthesized compounds have been screened for their antibacterial and antifungal activities. Most of them showed significant activity comparable with that of the standards Furacin and Flucanazol.
UR - http://www.scopus.com/inward/record.url?scp=74849104438&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=74849104438&partnerID=8YFLogxK
U2 - 10.1080/10426500802561450
DO - 10.1080/10426500802561450
M3 - Article
AN - SCOPUS:74849104438
SN - 1042-6507
VL - 184
SP - 2697
EP - 2703
JO - Phosphorus, Sulfur and Silicon and the Related Elements
JF - Phosphorus, Sulfur and Silicon and the Related Elements
IS - 10
ER -