@article{96b8a435a4fb43a180b3b34dafdfa17c,
title = "Synthesis, characterization and biological activities of some new benzo[b]thiophene derivatives",
abstract = "Benzo[b]thiophene molecules are found to be important tools in synthetic medicinal chemistry. They are of current interest due to their wide spectrum of pharmacological properties. In view of the biological activities of benzo[b]thiophene containing molecules, in this present research work, we propose the synthesis of some new benzo[b]thiophene derivatives such as thiadiazoles, oxadiazoles, pyrazolin & diaryl pyrazoles starting from 3-chlorobenzo[b]thiophene-2-carboxyl chloride. These newly synthesized compounds were characterized by elemental analyses, I.R, NMR and Mass spectral studies. Some of the selected compounds were screened for their antibacterial, antifungal and anti-inflammatory studies. Many of the molecules were found to be potent. {\textcopyright} 2009 Elsevier Masson SAS. All rights reserved.",
author = "A.M. Isloor and B. Kalluraya and {Sridhar Pai}, K.",
note = "Cited By :69 Export Date: 10 November 2017 CODEN: EJMCA Correspondence Address: Isloor, A.M.; Department of Chemistry, National Institute of Technology-Karnataka, Surathkal, Mangalore, 575 025, India; email: isloor@yahoo.com Chemicals/CAS: carrageenan, 9000-07-1, 9049-05-2, 9061-82-9, 9064-57-7; diclofenac, 15307-79-6, 15307-86-5; gum arabic, 9000-01-5; phenazone, 60-80-0; Anti-Infective Agents; Anti-Inflammatory Agents; Thiophenes; benzothiophene, 11095-43-5 References: Connor, D.T., Cetenko, W.A., Mullican, M.D., Sorenson, R.J., Unangst, P.C., Weikert, R.J., Adolphson, R.L., Conroy, M.C., (1992) J. Med. Chem., 35, p. 958; Wardakhani, W.W., Abdel-Salem, O.M.E., Elmegeed, G.A., (2008) Acta Pharm., 58, pp. 1-14; Mohamed, A.A.R., Shehab, M.A., El-Shenawy, S.M., (2009) Monatsh. Chem., 140, pp. 445-450; Graham, S.L., Shepard, K.L., Anderson, P.S., Baldwin, J.J., Best, D.B., Christy, M.E., Freedman, M.B., Habecker, C.N., (1989) J. Med. Chem., 32, pp. 2548-2554; Jones, C.D., Jevnikar, M.G., Pike, A.J., Peters, M.K., Black, L.J., Thompson, A.R., Falcone, J.F., Clements, J.A., (1984) J. Med. Chem., 27, pp. 1057-1066; Jordan, V.C., (2003) J. Med. Chem., 46, pp. 883-908; Jordan, V.C., (2003) J. Med. Chem., 46, pp. 1081-1111; Isloor, A.M., Kalluraya, B., Shetty, P., (2009) Eur. J. Med. Chem., 44, pp. 3784-3787; Hussain, M.I., Amir, M.J., (1986) Indian Chem. Soc., 63, pp. 317-320; Chiu, S.H.L., Huskey, S.E.W., (1998) Drug Metab. Dispos., 26, pp. 838-847; Zitouni, T.G., Kaplancikli, Z.A., Erol, K., Kilic, F.S., (1999) II Farmaco, 54, pp. 218-223; Holla, B.S., Kalluraya, B., (1988) Indian J. Chem., Sect. B, 27, pp. 683-685; Prasad, A.R., Ramalingam, T., Rao, A.B., Diwan, P.W., Sattur, P.B., (1989) Eur. J. Med. Chem., 24, pp. 199-201; El-Dawy, M.A., Omar, A.M.M.E., Hazzaa, A.I., (1983) J. Pharm. Sci., 72, pp. 45-50; Giri, S., Singh, H., Yadav, L.D.S., Khare, R.K., (1978) J. Indian Chem. Soc., 55, pp. 168-171; Mody, M.K., Prasad, A.R., Ramalingham, T., Suttur, P.B., (1982) J. Indian Chem. Soc., 59, pp. 769-770; Omar, F.A., Mahfouz, N.M., Rahman, M.A., (1996) Eur. J. Med. Chem., 31, pp. 819-825; El-Hawash, A.M.S., Badawey, E.-S.A.M., El-Ashmawey, M.I., (2006) Eur. J. Med. Chem., 41, pp. 155-165; Isloor, A.M., Kalluraya, B., Rao, M., (2000) J. Saudi Chem. Soc., 4, pp. 265-270; Castle, S.L., Buckhaults, P.J., Baldwin, L.J., Mckenny, J.D., (1987) J. Heterocycl. Chem., 24, pp. 1103-1108; (1989) Mackie and Mc. Cartney Practical Medicinal Microbiology. Thirteenth ed., p. 87. , Collee J.G., Duguid J.P., Fraser A.G., and Marmion B.P. (Eds); Winter, C.A., Risley, A., Nuss, G.W., (1962) Proc. Soc. Exp. Biol. Med., 111, pp. 544-547; Buttle, G.A.H., D'Arcy, P.F., Howard, E.M., Kellett, D.N., (1957) Nature, 179, p. 629; Singh, H., Ghosh, M.N., Pharm, J., (1968) Pharmacology, 20, pp. 316-317; Aboul, W.O., El-Metwalli, M.A.E., (1992) Arch. Pharm., 9, pp. 325-603; Isloor, A.M., Ph, (2001), D thesis submitted to Mangalore University;; Sridhar, K., (1991), Ph.D thesis submitted to Mangalore University;UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-73549090575&doi=10.1016%2fj.ejmech.2009.11.015&partnerID=40&md5=a78c5be6ff795af27d127813da81d3c9",
year = "2010",
doi = "10.1016/j.ejmech.2009.11.015",
language = "English",
volume = "45",
pages = "825--830",
journal = "CHIM.THER.",
issn = "0223-5234",
publisher = "Elsevier Masson SAS",
number = "2",
}