TY - JOUR
T1 - Synthesis, characterization and biological activities of some new benzo[b]thiophene derivatives
AU - Isloor, A.M.
AU - Kalluraya, B.
AU - Sridhar Pai, K.
N1 - Cited By :69
Export Date: 10 November 2017
CODEN: EJMCA
Correspondence Address: Isloor, A.M.; Department of Chemistry, National Institute of Technology-Karnataka, Surathkal, Mangalore, 575 025, India; email: [email protected]
Chemicals/CAS: carrageenan, 9000-07-1, 9049-05-2, 9061-82-9, 9064-57-7; diclofenac, 15307-79-6, 15307-86-5; gum arabic, 9000-01-5; phenazone, 60-80-0; Anti-Infective Agents; Anti-Inflammatory Agents; Thiophenes; benzothiophene, 11095-43-5
References: Connor, D.T., Cetenko, W.A., Mullican, M.D., Sorenson, R.J., Unangst, P.C., Weikert, R.J., Adolphson, R.L., Conroy, M.C., (1992) J. Med. Chem., 35, p. 958; Wardakhani, W.W., Abdel-Salem, O.M.E., Elmegeed, G.A., (2008) Acta Pharm., 58, pp. 1-14; Mohamed, A.A.R., Shehab, M.A., El-Shenawy, S.M., (2009) Monatsh. Chem., 140, pp. 445-450; Graham, S.L., Shepard, K.L., Anderson, P.S., Baldwin, J.J., Best, D.B., Christy, M.E., Freedman, M.B., Habecker, C.N., (1989) J. Med. Chem., 32, pp. 2548-2554; Jones, C.D., Jevnikar, M.G., Pike, A.J., Peters, M.K., Black, L.J., Thompson, A.R., Falcone, J.F., Clements, J.A., (1984) J. Med. Chem., 27, pp. 1057-1066; Jordan, V.C., (2003) J. Med. Chem., 46, pp. 883-908; Jordan, V.C., (2003) J. Med. Chem., 46, pp. 1081-1111; Isloor, A.M., Kalluraya, B., Shetty, P., (2009) Eur. J. Med. Chem., 44, pp. 3784-3787; Hussain, M.I., Amir, M.J., (1986) Indian Chem. Soc., 63, pp. 317-320; Chiu, S.H.L., Huskey, S.E.W., (1998) Drug Metab. Dispos., 26, pp. 838-847; Zitouni, T.G., Kaplancikli, Z.A., Erol, K., Kilic, F.S., (1999) II Farmaco, 54, pp. 218-223; Holla, B.S., Kalluraya, B., (1988) Indian J. Chem., Sect. B, 27, pp. 683-685; Prasad, A.R., Ramalingam, T., Rao, A.B., Diwan, P.W., Sattur, P.B., (1989) Eur. J. Med. Chem., 24, pp. 199-201; El-Dawy, M.A., Omar, A.M.M.E., Hazzaa, A.I., (1983) J. Pharm. Sci., 72, pp. 45-50; Giri, S., Singh, H., Yadav, L.D.S., Khare, R.K., (1978) J. Indian Chem. Soc., 55, pp. 168-171; Mody, M.K., Prasad, A.R., Ramalingham, T., Suttur, P.B., (1982) J. Indian Chem. Soc., 59, pp. 769-770; Omar, F.A., Mahfouz, N.M., Rahman, M.A., (1996) Eur. J. Med. Chem., 31, pp. 819-825; El-Hawash, A.M.S., Badawey, E.-S.A.M., El-Ashmawey, M.I., (2006) Eur. J. Med. Chem., 41, pp. 155-165; Isloor, A.M., Kalluraya, B., Rao, M., (2000) J. Saudi Chem. Soc., 4, pp. 265-270; Castle, S.L., Buckhaults, P.J., Baldwin, L.J., Mckenny, J.D., (1987) J. Heterocycl. Chem., 24, pp. 1103-1108; (1989) Mackie and Mc. Cartney Practical Medicinal Microbiology. Thirteenth ed., p. 87. , Collee J.G., Duguid J.P., Fraser A.G., and Marmion B.P. (Eds); Winter, C.A., Risley, A., Nuss, G.W., (1962) Proc. Soc. Exp. Biol. Med., 111, pp. 544-547; Buttle, G.A.H., D'Arcy, P.F., Howard, E.M., Kellett, D.N., (1957) Nature, 179, p. 629; Singh, H., Ghosh, M.N., Pharm, J., (1968) Pharmacology, 20, pp. 316-317; Aboul, W.O., El-Metwalli, M.A.E., (1992) Arch. Pharm., 9, pp. 325-603; Isloor, A.M., Ph, (2001), D thesis submitted to Mangalore University;; Sridhar, K., (1991), Ph.D thesis submitted to Mangalore University;UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-73549090575&doi=10.1016%2fj.ejmech.2009.11.015&partnerID=40&md5=a78c5be6ff795af27d127813da81d3c9
PY - 2010
Y1 - 2010
N2 - Benzo[b]thiophene molecules are found to be important tools in synthetic medicinal chemistry. They are of current interest due to their wide spectrum of pharmacological properties. In view of the biological activities of benzo[b]thiophene containing molecules, in this present research work, we propose the synthesis of some new benzo[b]thiophene derivatives such as thiadiazoles, oxadiazoles, pyrazolin & diaryl pyrazoles starting from 3-chlorobenzo[b]thiophene-2-carboxyl chloride. These newly synthesized compounds were characterized by elemental analyses, I.R, NMR and Mass spectral studies. Some of the selected compounds were screened for their antibacterial, antifungal and anti-inflammatory studies. Many of the molecules were found to be potent. © 2009 Elsevier Masson SAS. All rights reserved.
AB - Benzo[b]thiophene molecules are found to be important tools in synthetic medicinal chemistry. They are of current interest due to their wide spectrum of pharmacological properties. In view of the biological activities of benzo[b]thiophene containing molecules, in this present research work, we propose the synthesis of some new benzo[b]thiophene derivatives such as thiadiazoles, oxadiazoles, pyrazolin & diaryl pyrazoles starting from 3-chlorobenzo[b]thiophene-2-carboxyl chloride. These newly synthesized compounds were characterized by elemental analyses, I.R, NMR and Mass spectral studies. Some of the selected compounds were screened for their antibacterial, antifungal and anti-inflammatory studies. Many of the molecules were found to be potent. © 2009 Elsevier Masson SAS. All rights reserved.
U2 - 10.1016/j.ejmech.2009.11.015
DO - 10.1016/j.ejmech.2009.11.015
M3 - Article
SN - 0223-5234
VL - 45
SP - 825
EP - 830
JO - European Journal of Medicinal Chemistry
JF - European Journal of Medicinal Chemistry
IS - 2
ER -