TY - JOUR
T1 - Synthesis, characterization and biological activity of some new 1,3,4-oxadiazole bearing 2-flouro-4-methoxy phenyl moiety
AU - Chandrakantha, B.
AU - Shetty, Prakash
AU - Nambiyar, Vijesh
AU - Isloor, Nishitha
AU - Isloor, Arun M.
PY - 2010/3/1
Y1 - 2010/3/1
N2 - In the present study a series of new 1,3,4-oxadiazole derivatives containing 2-fluoro-4-methoxy moiety were synthesized. These newly synthesized compounds were characterized by NMR, mass spectral, IR spectral study and also by C, H, N analyses. All the newly synthesized compounds were screened for their antibacterial and antifungal studies. Antimicrobial studies revealed that compounds 4a and 4b showed significant antibacterial activity against Escherichia coli and Pseudomonas aeruginosa Compound 4i showed significant antifungal activity against C. albicans.
AB - In the present study a series of new 1,3,4-oxadiazole derivatives containing 2-fluoro-4-methoxy moiety were synthesized. These newly synthesized compounds were characterized by NMR, mass spectral, IR spectral study and also by C, H, N analyses. All the newly synthesized compounds were screened for their antibacterial and antifungal studies. Antimicrobial studies revealed that compounds 4a and 4b showed significant antibacterial activity against Escherichia coli and Pseudomonas aeruginosa Compound 4i showed significant antifungal activity against C. albicans.
UR - https://www.scopus.com/pages/publications/76049117192
UR - https://www.scopus.com/pages/publications/76049117192#tab=citedBy
U2 - 10.1016/j.ejmech.2009.11.046
DO - 10.1016/j.ejmech.2009.11.046
M3 - Article
C2 - 20004043
AN - SCOPUS:76049117192
SN - 0223-5234
VL - 45
SP - 1206
EP - 1210
JO - European Journal of Medicinal Chemistry
JF - European Journal of Medicinal Chemistry
IS - 3
ER -