Synthesis, characterization and single crystal studies of 3-cyclopropyl-3, 4-dihydroquinazolin-2(1H)-one

Nitinkumar S. Shetty, Y. F. Nadaf, Dinesh Bilehal, V. Shyamkumar, Santosh L. Gaonkar

Research output: Contribution to journalArticlepeer-review


The paper describes industrially scalable synthesis and single crystal studies of 3-cyclopropyl-3,4-dihydroquinazolin-2(1H)-one 4, a versatile intermediate in the synthesis of number of biologically active compounds. The target compound has been characterized by LC-MS, 1H NMR and IR. The crystal structure analysis shows that the title compound crystallizes in monoclinic class under the space group P 1 21/n 1 with cell parameters, a = 10.273(2) Å, b = 8.3227(19) Å, c = 11.623(3) Å, β = 104.980(3)°, V = 960.0(4) Å3 and Z=4.

Original languageEnglish
Pages (from-to)2707-2712
Number of pages6
JournalOriental Journal of Chemistry
Issue number5
Publication statusPublished - 2016

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Environmental Chemistry
  • Biochemistry
  • Drug Discovery


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