TY - JOUR
T1 - Synthesis, characterization and their anticonvulsant, anti-inflammatory studies of some novel chromeno oxadiazoles
AU - Ubaradka, S. R.
AU - Isloor, Arun M.
AU - Shetty, Prakash
AU - Shetty, Prashanth
AU - Isloor, Nishitha A.
PY - 2013/3/1
Y1 - 2013/3/1
N2 - In this study, a series of new 1,2,4-oxadiazole derivatives containing 3,4-dihydro-2H-chromen-2-amine moiety were synthesized by efficient microwave reaction of 2-amino-N′-hydroxychroman-3-carboxamidine and suitable aldehyde. Structures of all the synthesized compounds were confirmed by spectral studies and C, H, N analyses. Newly synthesized compounds were screened for their anticonvulsant and anti-inflammatory properties. Few of the compounds exhibited excellent anticonvulsant activity as compared to the standard drug Diazepam. Also compounds have exhibited moderate anti-inflammatory activity as compared to the standard drug Diclofenac sodium.
AB - In this study, a series of new 1,2,4-oxadiazole derivatives containing 3,4-dihydro-2H-chromen-2-amine moiety were synthesized by efficient microwave reaction of 2-amino-N′-hydroxychroman-3-carboxamidine and suitable aldehyde. Structures of all the synthesized compounds were confirmed by spectral studies and C, H, N analyses. Newly synthesized compounds were screened for their anticonvulsant and anti-inflammatory properties. Few of the compounds exhibited excellent anticonvulsant activity as compared to the standard drug Diazepam. Also compounds have exhibited moderate anti-inflammatory activity as compared to the standard drug Diclofenac sodium.
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U2 - 10.1007/s00044-012-0103-1
DO - 10.1007/s00044-012-0103-1
M3 - Article
AN - SCOPUS:84874107512
SN - 1054-2523
VL - 22
SP - 1497
EP - 1503
JO - Medicinal Chemistry Research
JF - Medicinal Chemistry Research
IS - 3
ER -