Synthesis, characterization, antimicrobial and single crystal X-ray crystallographic studies of some new sulfonyl, 4-chloro phenoxy benzene and dibenzoazepine substituted benzamides

B. S. Priya; S. Nanjunda Swamy; M. V. Tejesvi; Basappa; G. Sarala; S. L. Gaonkar; S. Naveen; J. Shashidhara Prasad; K. S. Rangappa

doi:10.1016/j.ejmech.2006.05.011

Synthesis, characterization, antimicrobial and single crystal X-ray crystallographic studies of some new sulfonyl, 4-chloro phenoxy benzene and dibenzoazepine substituted benzamides

B. S. Priya, S. Nanjunda Swamy, M. V. Tejesvi, Basappa, G. Sarala, S. L. Gaonkar, S. Naveen, J. Shashidhara Prasad, K. S. Rangappa

Department of Chemistry, Manipal Institute of Technology, Manipal

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

A new class of benzamide derivatives 3a(I-VI) and 3b(I-VI), bearing different bioactive moieties were synthesized and evaluated for their efficacy as antimicrobials in vitro. Compounds 3bVI, 3aII, 3aV, 3bIII, 3aVI, 3bII showed significant antibacterial activity and 3bIII, 3bII, 3aIV, 3bV, 3bVI, 3aI exhibit significant antifungal activity. The title compounds are characterized by spectral and elemental analysis. Compounds 2-methoxy-N-[4-(thiazol-2-yl-sulfamoyl)-phenyl]-benzamide 3aII and 2-(2-(2-ethoxybenzoylamino) phenethyl)-N-(2-ethoxybenzoyl) benzenamine 3bV are characterized by the single crystal X-ray studies. Compound 3aII crystallizes in monoclinic space group P2₁ and 3bV in triclinic space group P-1. Compounds 3aII and 3bV exhibit both inter and intra molecular hydrogen bonding.

Original language	English
Pages (from-to)	1262-1270
Number of pages	9
Journal	European Journal of Medicinal Chemistry
Volume	41
Issue number	11
DOIs	https://doi.org/10.1016/j.ejmech.2006.05.011
Publication status	Published - 11-2006

All Science Journal Classification (ASJC) codes

Pharmacology
Drug Discovery
Organic Chemistry

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10.1016/j.ejmech.2006.05.011

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Priya, B. S., Nanjunda Swamy, S., Tejesvi, M. V., Basappa, Sarala, G., Gaonkar, S. L., Naveen, S., Shashidhara Prasad, J., & Rangappa, K. S. (2006). Synthesis, characterization, antimicrobial and single crystal X-ray crystallographic studies of some new sulfonyl, 4-chloro phenoxy benzene and dibenzoazepine substituted benzamides. European Journal of Medicinal Chemistry, 41(11), 1262-1270. https://doi.org/10.1016/j.ejmech.2006.05.011

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title = "Synthesis, characterization, antimicrobial and single crystal X-ray crystallographic studies of some new sulfonyl, 4-chloro phenoxy benzene and dibenzoazepine substituted benzamides",

abstract = "A new class of benzamide derivatives 3a(I-VI) and 3b(I-VI), bearing different bioactive moieties were synthesized and evaluated for their efficacy as antimicrobials in vitro. Compounds 3bVI, 3aII, 3aV, 3bIII, 3aVI, 3bII showed significant antibacterial activity and 3bIII, 3bII, 3aIV, 3bV, 3bVI, 3aI exhibit significant antifungal activity. The title compounds are characterized by spectral and elemental analysis. Compounds 2-methoxy-N-[4-(thiazol-2-yl-sulfamoyl)-phenyl]-benzamide 3aII and 2-(2-(2-ethoxybenzoylamino) phenethyl)-N-(2-ethoxybenzoyl) benzenamine 3bV are characterized by the single crystal X-ray studies. Compound 3aII crystallizes in monoclinic space group P21 and 3bV in triclinic space group P-1. Compounds 3aII and 3bV exhibit both inter and intra molecular hydrogen bonding.",

author = "Priya, {B. S.} and {Nanjunda Swamy}, S. and Tejesvi, {M. V.} and Basappa and G. Sarala and Gaonkar, {S. L.} and S. Naveen and {Shashidhara Prasad}, J. and Rangappa, {K. S.}",

year = "2006",

month = nov,

doi = "10.1016/j.ejmech.2006.05.011",

language = "English",

volume = "41",

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Priya, BS, Nanjunda Swamy, S, Tejesvi, MV, Basappa, Sarala, G, Gaonkar, SL, Naveen, S, Shashidhara Prasad, J & Rangappa, KS 2006, 'Synthesis, characterization, antimicrobial and single crystal X-ray crystallographic studies of some new sulfonyl, 4-chloro phenoxy benzene and dibenzoazepine substituted benzamides', European Journal of Medicinal Chemistry, vol. 41, no. 11, pp. 1262-1270. https://doi.org/10.1016/j.ejmech.2006.05.011

Synthesis, characterization, antimicrobial and single crystal X-ray crystallographic studies of some new sulfonyl, 4-chloro phenoxy benzene and dibenzoazepine substituted benzamides. / Priya, B. S.; Nanjunda Swamy, S.; Tejesvi, M. V. et al.
In: European Journal of Medicinal Chemistry, Vol. 41, No. 11, 11.2006, p. 1262-1270.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

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AU - Priya, B. S.

AU - Nanjunda Swamy, S.

AU - Tejesvi, M. V.

AU - Basappa,

AU - Sarala, G.

AU - Gaonkar, S. L.

AU - Naveen, S.

AU - Shashidhara Prasad, J.

AU - Rangappa, K. S.

PY - 2006/11

Y1 - 2006/11

N2 - A new class of benzamide derivatives 3a(I-VI) and 3b(I-VI), bearing different bioactive moieties were synthesized and evaluated for their efficacy as antimicrobials in vitro. Compounds 3bVI, 3aII, 3aV, 3bIII, 3aVI, 3bII showed significant antibacterial activity and 3bIII, 3bII, 3aIV, 3bV, 3bVI, 3aI exhibit significant antifungal activity. The title compounds are characterized by spectral and elemental analysis. Compounds 2-methoxy-N-[4-(thiazol-2-yl-sulfamoyl)-phenyl]-benzamide 3aII and 2-(2-(2-ethoxybenzoylamino) phenethyl)-N-(2-ethoxybenzoyl) benzenamine 3bV are characterized by the single crystal X-ray studies. Compound 3aII crystallizes in monoclinic space group P21 and 3bV in triclinic space group P-1. Compounds 3aII and 3bV exhibit both inter and intra molecular hydrogen bonding.

AB - A new class of benzamide derivatives 3a(I-VI) and 3b(I-VI), bearing different bioactive moieties were synthesized and evaluated for their efficacy as antimicrobials in vitro. Compounds 3bVI, 3aII, 3aV, 3bIII, 3aVI, 3bII showed significant antibacterial activity and 3bIII, 3bII, 3aIV, 3bV, 3bVI, 3aI exhibit significant antifungal activity. The title compounds are characterized by spectral and elemental analysis. Compounds 2-methoxy-N-[4-(thiazol-2-yl-sulfamoyl)-phenyl]-benzamide 3aII and 2-(2-(2-ethoxybenzoylamino) phenethyl)-N-(2-ethoxybenzoyl) benzenamine 3bV are characterized by the single crystal X-ray studies. Compound 3aII crystallizes in monoclinic space group P21 and 3bV in triclinic space group P-1. Compounds 3aII and 3bV exhibit both inter and intra molecular hydrogen bonding.

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Synthesis, characterization, antimicrobial and single crystal X-ray crystallographic studies of some new sulfonyl, 4-chloro phenoxy benzene and dibenzoazepine substituted benzamides

Abstract

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