Synthesis, characterization, DNA binding, and cytotoxic studies of dinuclear complexes of palladium(II) and platinum(II) with 2,2-bipyridine and α,ω-diaminoalkane-N,N′-diacetic acid

Nidhi Jain; R. Mittal; T. S. Srivastava; K. Satyamoorthy; M. P. Chitnis

doi:10.1016/0162-0134(94)85023-2

Synthesis, characterization, DNA binding, and cytotoxic studies of dinuclear complexes of palladium(II) and platinum(II) with 2,2-bipyridine and α,ω-diaminoalkane-N,N′-diacetic acid

Nidhi Jain
, R. Mittal
, T. S. Srivastava^*
, K. Satyamoorthy
, M. P. Chitnis

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

The synthesis of four α,ω-diaminoalkane-N,N′-diacetic acid and their dinuclear 2,2′-bipyridine palladium(II) and platinum(II) complexes of general formula [M₂(bipy)₂(DADA)] (NO₃)₂ (where M is Pd(II) or Pt(II), bipy is 2,2′-bipyridine, DADA is dianion of 1,4-diaminobutane-N,N′-diacetic acid (DBDA), 1,6-diaminohexane-N,N′-diacetic acid (DHDA), 1,8-diaminooctane-N,N′-diacetic acid (DODA), or 1,10-diaminodecane-N-N′-diacetic acid (DDDA) has been achieved. They have been characterized by elemental analysis, conductivity measurements, electronic absorption, and infrared and variable temperature ¹H NMR spectroscopy. The above eight dinuclear palladium(II) and platinum(II) complexes have been tested for cytotoxicity against P388 lymphocytic leukemia cells. Out of them, [Pt₂(bipy)₂(DDDA)(NO₃)₂ and [Pd₂(bipy)₂(DBDA)](NO₃)₂ show lower I.D.₅₀ values as compared to cisplatin. The binding of [Pt₂(bipy)₂(DODA)](NO₃)₂ and [M₂(bipy)₂(DHDA)](NO₃)₂ with calf thymus DNA (deoxyribonucleic acid) has also been studied. [Pt₂(bipy)₂(DODA/DHDA)](NO₃)2 complexes show high positive cooperative binding to DNA, with Hill coefficients of 1.6 to 1.9, respectively, whereas [Pd₂(bipy)₂(DHDA)](NO₃) gives a biphasic Scatchard plot with two different binding sites or with negative cooperativity.

Original language	English
Pages (from-to)	79-94
Number of pages	16
Journal	Journal of Inorganic Biochemistry
Volume	53
Issue number	2
DOIs	https://doi.org/10.1016/0162-0134(94)85023-2
Publication status	Published - 01-02-1994

All Science Journal Classification (ASJC) codes

Biochemistry
Inorganic Chemistry

Access to Document

10.1016/0162-0134(94)85023-2

Cite this

@article{3d10ba2c1cbf4856a350059d2bf18dee,

title = "Synthesis, characterization, DNA binding, and cytotoxic studies of dinuclear complexes of palladium(II) and platinum(II) with 2,2-bipyridine and α,ω-diaminoalkane-N,N′-diacetic acid",

abstract = "The synthesis of four α,ω-diaminoalkane-N,N′-diacetic acid and their dinuclear 2,2′-bipyridine palladium(II) and platinum(II) complexes of general formula [M2(bipy)2(DADA)] (NO3)2 (where M is Pd(II) or Pt(II), bipy is 2,2′-bipyridine, DADA is dianion of 1,4-diaminobutane-N,N′-diacetic acid (DBDA), 1,6-diaminohexane-N,N′-diacetic acid (DHDA), 1,8-diaminooctane-N,N′-diacetic acid (DODA), or 1,10-diaminodecane-N-N′-diacetic acid (DDDA) has been achieved. They have been characterized by elemental analysis, conductivity measurements, electronic absorption, and infrared and variable temperature 1H NMR spectroscopy. The above eight dinuclear palladium(II) and platinum(II) complexes have been tested for cytotoxicity against P388 lymphocytic leukemia cells. Out of them, [Pt2(bipy)2(DDDA)(NO3)2 and [Pd2(bipy)2(DBDA)](NO3)2 show lower I.D.50 values as compared to cisplatin. The binding of [Pt2(bipy)2(DODA)](NO3)2 and [M2(bipy)2(DHDA)](NO3)2 with calf thymus DNA (deoxyribonucleic acid) has also been studied. [Pt2(bipy)2(DODA/DHDA)](NO3)2 complexes show high positive cooperative binding to DNA, with Hill coefficients of 1.6 to 1.9, respectively, whereas [Pd2(bipy)2(DHDA)](NO3) gives a biphasic Scatchard plot with two different binding sites or with negative cooperativity.",

author = "Nidhi Jain and R. Mittal and Srivastava, \{T. S.\} and K. Satyamoorthy and Chitnis, \{M. P.\}",

year = "1994",

month = feb,

day = "1",

doi = "10.1016/0162-0134(94)85023-2",

language = "English",

volume = "53",

pages = "79--94",

journal = "Journal of Inorganic Biochemistry",

issn = "0162-0134",

publisher = "Elsevier Inc.",

number = "2",

}

Synthesis, characterization, DNA binding, and cytotoxic studies of dinuclear complexes of palladium(II) and platinum(II) with 2,2-bipyridine and α,ω-diaminoalkane-N,N′-diacetic acid. / Jain, Nidhi; Mittal, R.; Srivastava, T. S. et al.
In: Journal of Inorganic Biochemistry, Vol. 53, No. 2, 01.02.1994, p. 79-94.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Synthesis, characterization, DNA binding, and cytotoxic studies of dinuclear complexes of palladium(II) and platinum(II) with 2,2-bipyridine and α,ω-diaminoalkane-N,N′-diacetic acid

AU - Jain, Nidhi

AU - Mittal, R.

AU - Srivastava, T. S.

AU - Satyamoorthy, K.

AU - Chitnis, M. P.

PY - 1994/2/1

Y1 - 1994/2/1

N2 - The synthesis of four α,ω-diaminoalkane-N,N′-diacetic acid and their dinuclear 2,2′-bipyridine palladium(II) and platinum(II) complexes of general formula [M2(bipy)2(DADA)] (NO3)2 (where M is Pd(II) or Pt(II), bipy is 2,2′-bipyridine, DADA is dianion of 1,4-diaminobutane-N,N′-diacetic acid (DBDA), 1,6-diaminohexane-N,N′-diacetic acid (DHDA), 1,8-diaminooctane-N,N′-diacetic acid (DODA), or 1,10-diaminodecane-N-N′-diacetic acid (DDDA) has been achieved. They have been characterized by elemental analysis, conductivity measurements, electronic absorption, and infrared and variable temperature 1H NMR spectroscopy. The above eight dinuclear palladium(II) and platinum(II) complexes have been tested for cytotoxicity against P388 lymphocytic leukemia cells. Out of them, [Pt2(bipy)2(DDDA)(NO3)2 and [Pd2(bipy)2(DBDA)](NO3)2 show lower I.D.50 values as compared to cisplatin. The binding of [Pt2(bipy)2(DODA)](NO3)2 and [M2(bipy)2(DHDA)](NO3)2 with calf thymus DNA (deoxyribonucleic acid) has also been studied. [Pt2(bipy)2(DODA/DHDA)](NO3)2 complexes show high positive cooperative binding to DNA, with Hill coefficients of 1.6 to 1.9, respectively, whereas [Pd2(bipy)2(DHDA)](NO3) gives a biphasic Scatchard plot with two different binding sites or with negative cooperativity.

AB - The synthesis of four α,ω-diaminoalkane-N,N′-diacetic acid and their dinuclear 2,2′-bipyridine palladium(II) and platinum(II) complexes of general formula [M2(bipy)2(DADA)] (NO3)2 (where M is Pd(II) or Pt(II), bipy is 2,2′-bipyridine, DADA is dianion of 1,4-diaminobutane-N,N′-diacetic acid (DBDA), 1,6-diaminohexane-N,N′-diacetic acid (DHDA), 1,8-diaminooctane-N,N′-diacetic acid (DODA), or 1,10-diaminodecane-N-N′-diacetic acid (DDDA) has been achieved. They have been characterized by elemental analysis, conductivity measurements, electronic absorption, and infrared and variable temperature 1H NMR spectroscopy. The above eight dinuclear palladium(II) and platinum(II) complexes have been tested for cytotoxicity against P388 lymphocytic leukemia cells. Out of them, [Pt2(bipy)2(DDDA)(NO3)2 and [Pd2(bipy)2(DBDA)](NO3)2 show lower I.D.50 values as compared to cisplatin. The binding of [Pt2(bipy)2(DODA)](NO3)2 and [M2(bipy)2(DHDA)](NO3)2 with calf thymus DNA (deoxyribonucleic acid) has also been studied. [Pt2(bipy)2(DODA/DHDA)](NO3)2 complexes show high positive cooperative binding to DNA, with Hill coefficients of 1.6 to 1.9, respectively, whereas [Pd2(bipy)2(DHDA)](NO3) gives a biphasic Scatchard plot with two different binding sites or with negative cooperativity.

UR - https://www.scopus.com/pages/publications/0028338818

UR - https://www.scopus.com/pages/publications/0028338818#tab=citedBy

U2 - 10.1016/0162-0134(94)85023-2

DO - 10.1016/0162-0134(94)85023-2

M3 - Article

AN - SCOPUS:0028338818

SN - 0162-0134

VL - 53

SP - 79

EP - 94

JO - Journal of Inorganic Biochemistry

JF - Journal of Inorganic Biochemistry

IS - 2

ER -

Synthesis, characterization, DNA binding, and cytotoxic studies of dinuclear complexes of palladium(II) and platinum(II) with 2,2-bipyridine and α,ω-diaminoalkane-N,N′-diacetic acid

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this