Synthesis, invitro and invivo anticancer activity of substituted imidazolones

Aravinda Pai; Rajeev K. Singla; Alex Joseph; Tukaram Kedar; Angel Treasa Thomas

Synthesis, invitro and invivo anticancer activity of substituted imidazolones

Aravinda Pai, Rajeev K. Singla, Alex Joseph, Tukaram Kedar, Angel Treasa Thomas

Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal
Department of Pharmaceutical Biotechnology, Manipal College of Pharmaceutical Sciences, Manipal

Research output: Contribution to journal › Letter › peer-review

1 Citation (Scopus)

Abstract

Different substitutions of imidazolones were synthesized and screened first for the in vitro anticancer activity at concentrations of 12.5 – 100 μg/ ml on Hela cell lines. Out of these eight synthesized compounds, the most active compound 3C-BRS was selected for in vivo anticancer activity using Ehrlich ascites carcinoma (EAC), using liquid tumor model. So 3CBRS was found be an effective anticancer agent.

Original language	English
Pages (from-to)	933-942
Number of pages	10
Journal	Pharmacologyonline
Volume	2
Publication status	Published - 30-08-2009

All Science Journal Classification (ASJC) codes

Pharmacology
Drug Discovery

Cite this

@article{89a2dea9d76b44828c0062ae562f54ce,

title = "Synthesis, invitro and invivo anticancer activity of substituted imidazolones",

abstract = "Different substitutions of imidazolones were synthesized and screened first for the in vitro anticancer activity at concentrations of 12.5 – 100 μg/ ml on Hela cell lines. Out of these eight synthesized compounds, the most active compound 3C-BRS was selected for in vivo anticancer activity using Ehrlich ascites carcinoma (EAC), using liquid tumor model. So 3CBRS was found be an effective anticancer agent.",

author = "Aravinda Pai and Singla, {Rajeev K.} and Alex Joseph and Tukaram Kedar and Thomas, {Angel Treasa}",

year = "2009",

month = aug,

day = "30",

language = "English",

volume = "2",

pages = "933--942",

journal = "Pharmacologyonline",

issn = "1827-8620",

publisher = "SILAE (Italo-Latin American Society of Ethnomedicine)",

}

TY - JOUR

T1 - Synthesis, invitro and invivo anticancer activity of substituted imidazolones

AU - Pai, Aravinda

AU - Singla, Rajeev K.

AU - Joseph, Alex

AU - Kedar, Tukaram

AU - Thomas, Angel Treasa

PY - 2009/8/30

Y1 - 2009/8/30

N2 - Different substitutions of imidazolones were synthesized and screened first for the in vitro anticancer activity at concentrations of 12.5 – 100 μg/ ml on Hela cell lines. Out of these eight synthesized compounds, the most active compound 3C-BRS was selected for in vivo anticancer activity using Ehrlich ascites carcinoma (EAC), using liquid tumor model. So 3CBRS was found be an effective anticancer agent.

AB - Different substitutions of imidazolones were synthesized and screened first for the in vitro anticancer activity at concentrations of 12.5 – 100 μg/ ml on Hela cell lines. Out of these eight synthesized compounds, the most active compound 3C-BRS was selected for in vivo anticancer activity using Ehrlich ascites carcinoma (EAC), using liquid tumor model. So 3CBRS was found be an effective anticancer agent.

UR - http://www.scopus.com/inward/record.url?scp=84969724285&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84969724285&partnerID=8YFLogxK

M3 - Letter

AN - SCOPUS:84969724285

SN - 1827-8620

VL - 2

SP - 933

EP - 942

JO - Pharmacologyonline

JF - Pharmacologyonline

ER -

Synthesis, invitro and invivo anticancer activity of substituted imidazolones

Abstract

All Science Journal Classification (ASJC) codes

Other files and links

Fingerprint

Cite this